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abiraterone

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Origin: China

Cas No: 154229-19-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
154229-19-3
Other Names:
abiraterone
MF:
C24H31NO
EINECS No.:
154229-19-3
Place of Origin:
Shanghai, China
Grade Standard:
Agriculture Grade, Food Grade, Industrial Grade, Medicine Grade, Reagent Grade
Purity:
99%min
Appearance:
White Powder
Application:
Medicine
Brand Name:
TERPPON
Model Number:
9
color:
White
Packaging&Delivery
Packaging Details
in 25kg drum
Port
Shanghai
Lead Time:
1 week

Property

CAS No.: 154229-19-3 Formula: C24H31NO Molecular Weight: 349.50900

Description

Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) – i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. It is a prodrug to the active agent abiraterone, and is marketed by Janssen Biotech under the trade name Zytiga. In addition, Intas Pharmaceuticals markets the drug under the trade name Abiratas, Cadila Pharmaceuticals markets the drug as Abretone, and Glenmark Pharmaceuticals as Abirapro.
Abiraterone acetate was approved by the United States Food and Drug Administration on April 28, 2011. The FDA press release made reference to a phase III clinical trial in which abiraterone use was associated with a median survival of 14.8 months versus 10.9 months with placebo; the study was stopped early because of the successful outcome.

Basic Info

Chemical Name	abiraterone
Synonyms	Abiraterone; (3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol;
CAS No.	154229-19-3
Molecular Formula	C24H31NO
Molecular Weight	349.50900
PSA	33.12000
LogP	5.39860

Properties

Appearance & Physical State	white solid
Density	1.14g/cm3
Boiling Point	500.2ºC at 760mmHg
Flash Point	256.3ºC
Refractive Index	1.605
Vapor Pressure	7.99E-11mmHg at 25°C

Safety Info

HS Code	2933399090

Synthesis Route

abiraterone acetate→abiraterone
3-((3S,8R,9S,10R,13S,14S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine→abiraterone
→abiraterone

Precursor

3-((3S,8R,9S,10R,13S,14S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine
N'-(3-hydroxy-10,13-dimethyl-3,4,7,8,9,11,12,13,15,16-decahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-4-methylbenzenesulfonohydrazide
abiraterone acetate
3-bromopyridine

Downstream Product

3β-Acetoxy-16-(3β-acetoxyandrosta-5,16-dien-17-yl)-17-(3-pyridyl)androsta-5,16-diene
abiraterone acetate

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