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abacavir

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начало: Китай

Кас Но: 136470-78-5

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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CAS No.: 136470-78-5 Formula: C14H18N6O Molecular Weight: 286.33200

Description

Abacavir (ABC) is an antiretroviral medication used to prevent and treat HIV/AIDS. Viral strains that are resistant to zidovudine (AZT) or lamivudine (3TC) are generally, but not always, sensitive to abacavir.
It is well tolerated: the main side effect is hypersensitivity, which can be severe, and in rare cases, fatal. Genetic testing can indicate whether an individual is likely to be hypersensitive; over 90% of people can safely take abacavir. It is of the nucleoside analog reverse transcriptase inhibitor (NRTI) type and is in the class of carbocyclic nucleosides.
It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is available in the combination formulations abacavir/lamivudine/zidovudine, abacavir/dolutegravir/lamivudine, and abacavir/lamivudine. As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.

Basic Info

Chemical Name	abacavir
Synonyms	(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; Abacavir;
CAS No.	136470-78-5
Molecular Formula	C14H18N6O
Molecular Weight	286.33200
PSA	101.88000
LogP	1.74650

Properties

Appearance & Physical State	white powder
Density	1.7g/cm3
Boiling Point	636ºC at 760 mmHg
Flash Point	338.4ºC
Refractive Index	1.864
Vapor Pressure	4.77E-17mmHg at 25°C

Safety Info

RTECS	TE3850000
Hazard Class	6.1(b)
Safety Statements	S36/37; S45; S60; S61
Packing Group	III
RIDADR	UN 2810
Risk Statements	R21; R23/25; R43; R50/53
Hazard Codes	T; N

Synthesis Route

(-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide→abacavir
6-cyclopropylamine-9-((1R,4S)-4-((triisopropylsilyloxy)methyl)cyclopent-2-enyl)-9H-purin-2-amine→abacavir
6-chloroguanine+Cyclopropylamine→abacavir

Precursor

Cyclopropylamine
cis-3-benzoyloxy-4-(hydroxymethyl)cyclopentene
(-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide
6-chloroguanine

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