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abacavir

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Origin: China

Cas No: 136470-78-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 136470-78-5 Formula: C14H18N6O Molecular Weight: 286.33200

    Description

    Abacavir (ABC) is an antiretroviral medication used to prevent and treat HIV/AIDS. Viral strains that are resistant to zidovudine (AZT) or lamivudine (3TC) are generally, but not always, sensitive to abacavir.
    It is well tolerated: the main side effect is hypersensitivity, which can be severe, and in rare cases, fatal. Genetic testing can indicate whether an individual is likely to be hypersensitive; over 90% of people can safely take abacavir. It is of the nucleoside analog reverse transcriptase inhibitor (NRTI) type and is in the class of carbocyclic nucleosides.
    It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is available in the combination formulations abacavir/lamivudine/zidovudine, abacavir/dolutegravir/lamivudine, and abacavir/lamivudine. As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.

    Basic Info

    Chemical Name abacavir
    Synonyms

    (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol;
    Abacavir;

    CAS No. 136470-78-5
    Molecular Formula C14H18N6O
    Molecular Weight 286.33200
    PSA 101.88000
    LogP 1.74650

    Properties

    Appearance & Physical State white powder
    Density 1.7g/cm3
    Boiling Point 636ºC at 760 mmHg
    Flash Point 338.4ºC
    Refractive Index 1.864
    Vapor Pressure 4.77E-17mmHg at 25°C

    Safety Info

    RTECS TE3850000
    Hazard Class 6.1(b)
    Safety Statements S36/37; S45; S60; S61
    Packing Group III
    RIDADR UN 2810
    Risk Statements R21; R23/25; R43; R50/53
    Hazard Codes T; N

    Synthesis Route

    (-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramideabacavir
    6-cyclopropylamine-9-((1R,4S)-4-((triisopropylsilyloxy)methyl)cyclopent-2-enyl)-9H-purin-2-amineabacavir
    6-chloroguanine+Cyclopropylamineabacavir

    Precursor

    Cyclopropylamine
    cis-3-benzoyloxy-4-(hydroxymethyl)cyclopentene
    (-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide
    6-chloroguanine

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