Início > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

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Origem: China

Cas No: 38092-88-5

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 80 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Descrição do produto

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CAS No.: 38092-88-5 Formula: C20H21ClN2 Molecular Weight: 324.84700

Description

Loratadine Impurity. An isomer of N-Methyl Desloratadine with antianaphylactic and antihistaminic activity.

Basic Info

Chemical Name	9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
Synonyms	9-chloro azatadine; 9-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 9-chloro-11-(1-methyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Dechloro-9-chloro-N-methyl Desloratadine;
CAS No.	38092-88-5
Molecular Formula	C20H21ClN2
Molecular Weight	324.84700
PSA	16.13000
LogP	4.29900

Synthesis Route

7-Chlor-10,11-dihydro-4-aza-5H-dibenzo(a,d)cyclohepten-5-on→9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
N-tert-butyl-3-methylpyridine-2-carboxamide→9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
3-(4-chloro-phenethyl)-pyridine-2-carbonitrile→9-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

Precursor

3-(4-chloro-phenethyl)-pyridine-2-carbonitrile
magnesium,1-methylpiperidin-4-ide,chloride
7-Chlor-10,11-dihydro-4-aza-5H-dibenzo(a,d)cyclohepten-5-on
4-Chlorobenzyl Chloride

Downstream Product

9-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
ethyl 4-(9-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidine-1-carboxylate

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