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8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-5-ol

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Origin: China

Cas No: 117811-12-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 117811-12-8 Formula: C19H19ClN2O Molecular Weight: 326.82000

Description

A hydroxylated metabolite of Desloratadine.

Basic Info

Chemical Name	8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-5-ol
Synonyms	5-Hydroxydesloratadine; 5-OH desloratadine;
CAS No.	117811-12-8
Molecular Formula	C19H19ClN2O
Molecular Weight	326.82000
PSA	45.15000
LogP	3.83860

Synthesis Route

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-5-one→8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-5-ol
2,2,2-Trichloroethyl 4-(8-Chloro-5,6-dihydro-5-hydroxy-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ylidene)-1-piperidinecarboxylate→8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-5-ol
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one→8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-5-ol

Precursor

2,2,2-Trichloroethyl 4-(8-Chloro-5,6-dihydro-5-hydroxy-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ylidene)-1-piperidinecarboxylate
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-5-one
8-chloro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one

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