Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 8-Chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

8-Chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

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Origin: China

Cas No: 38089-93-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 38089-93-9 Formula: C20H23ClN2O Molecular Weight: 342.86200

Description

11-Hydroxy-N-methyl Dihydroloratadine is an impurity of Loratadine.

Basic Info

Chemical Name	8-Chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
Synonyms	11-Hydroxy-N-methyl Dihydro Loratadine;
CAS No.	38089-93-9
Molecular Formula	C20H23ClN2O
Molecular Weight	342.86200
PSA	36.36000
LogP	3.34920

Properties

Density	1.244 g/cm3
Boiling Point	478.12ºC at 760 mmHg
Refractive Index	1.621

Safety Info

HS Code	2933990090

Synthesis Route

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one+magnesium,1-methylpiperidin-4-ide,chloride→8-Chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
4-Chloro-1-methylpiperidine+8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one→8-Chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

Precursor

magnesium,1-methylpiperidin-4-ide,chloride
4-Chloro-1-methylpiperidine
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Downstream Product

desloratadine
Loratadine
N-Methyl Desloratadine

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