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8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

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Origem: China

Cas No: 130642-57-8

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 80 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Especificação de produtos
Descrição do produto

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CAS No.: 130642-57-8 Formula: C20H21BrN2 Molecular Weight: 369.29800

Description

A derivative of Loratadine as dual antagonist of platelet activating factor (PAF) and histamine.

Basic Info

Chemical Name	8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
Synonyms	8-Deschloro-8-bromo-N-methyl Desloratadine;
CAS No.	130642-57-8
Molecular Formula	C20H21BrN2
Molecular Weight	369.29800
PSA	16.13000
LogP	4.40810

Synthesis Route

{3-[2-(3-Bromo-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone→8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
N-tert-butyl-3-methylpyridine-2-carboxamide→8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
3-[2-(3-Bromo-phenyl)-ethyl]-pyridine-2-carbonitrile→8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

Precursor

3-[2-(3-Bromo-phenyl)-ethyl]-pyridine-2-carbonitrile
3-Bromobenzyl chloride
{3-[2-(3-Bromo-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone

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