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7-nitro-1H-indazole

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Origin: China

Cas No: 2942-42-9

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 2942-42-9 Formula: C7H5N3O2 Molecular Weight: 163.13300

    Description

    7-Nitroindazole, or 7-NI, is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. Nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO). Nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowing cell signalling, so nitroindazole indirectly inhibits this signalling process. Other inhibitors exist such as 3-bromo-7-nitroindazole, which is more potent but less specific, or NPA (N-propyl-L-arginine), which acts on a different site.

    Basic Info

    Chemical Name 7-nitro-1H-indazole
    Synonyms

    1H-Indazole,7-nitro;
    EINECS 220-934-4;
    7-Nitroindazole;
    7-Nitro-1H-indazole;
    1H-Indazole, 7-nitro-;
    nitro-7 indazole;
    7-NI;

    CAS No. 2942-42-9
    Molecular Formula C7H5N3O2
    Molecular Weight 163.13300
    PSA 74.50000
    LogP 1.99430

    Properties

    Appearance & Physical State Orange-Yellow Solid
    Density 1.525 g/cm3
    Boiling Point 383.3ºC at 760 mmHg
    Melting Point 190ºC
    Flash Point 185.6ºC
    Refractive Index 1.74
    Water Solubility slightly soluble
    Storage Condition -20ºC
    Vapor Pressure 9.79E-06mmHg at 25°C

    Safety Info

    RTECS NK7962200
    Safety Statements S53-S22-S36/37/39-S45
    HS Code 2933990090
    WGK Germany 3
    RIDADR UN 2811
    Risk Statements R60; R40
    Hazard Codes T
    Symbol GHS06, GHS08
    Caution Statement P201; P281; P301 + P310; P305 + P351 + P338; P308 + P313
    Signal Word Danger
    Hazard Declaration H301; H319; H351; H360

    Synthesis Route

    2-Methyl-6-nitroaniline7-nitro-1H-indazole
    tert-butyl 7-nitroindazole-1-carboxylate7-nitro-1H-indazole
    3-Nitrosalicylaldehyde7-nitro-1H-indazole

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    - Mutation in microorganisms - 100 nmol/plate -

    Precursor

    tert-butyl 7-nitroindazole-1-carboxylate
    2-Methyl-6-nitroaniline
    3-Nitrosalicylaldehyde

    Downstream Product

    7-Amino-2-methylindazole
    7-Amino-1-methyl-1H-indazole
    7-iodo-1H-indazole
    3-Bromo-1H-indazole-7-carbonitrile

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