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Главная > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
Изображение 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester

7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester

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начало: Китай

Кас Но: 147118-39-6

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта

  • Quick Details

    CAS No.:
    147118-39-6
    Other Names:
    Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl
    MF:
    C23H28FN3O6S
    EINECS No.:
    604-567-0
    Place of Origin:
    Shandong, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    98.0-102.0%
    Brand Name:
    Natural Micron Pharm Tech
    Model Number:
    147118-39-6
    Application:
    Pharmaceutical Intermediates
    Appearance:
    White powder
    Product Name:
    5-Oxorosuvastatin Methyl Ester
    CAS:
    147118-39-6
    Grade:
    Phamaceutical Grade
    Assay:
    98.0~102.0%
    Color:
    White powder
    Molecular Weight:
    493.55
    Molecular Formula:
    C23H28FN3O6S
    EINECS:
    604-567-0
    MOQ:
    1kg
    Sample:
    Free sample available

    Packaging&Delivery

    Packaging Details
    25kg/Drum
    200kg/Drum
    Port
    Shanghai/Shenzhen/Qingdao
    Lead Time:
    Quantity(Kilograms)1 - 500>500
    Est. Time(days)3To be negotiated

  • Property

    CAS No.: 147118-39-6 Formula: C23H28FN3O6S Molecular Weight: 493.54800

    Description

    5-Oxorosuvastatin methyl ester is an intermediate in the synthesis of Rosuvasatatin (calcium salt: R700500), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that decreases high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations in the blood.

    Basic Info

    Chemical Name 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
    Synonyms

    Methyl 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL]-(3R,5R)-DIHYDROXY-(E)-6-HEPTENATE;
    (R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-3-hydroxy-5-oxohept-6-enoate;
    Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate;
    methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptanate;
    methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate;
    methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate;
    methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoate;
    Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methanesul fonylaMino) pyriMidin-5-y;
    7-[4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl-methyl-amino)pyrimidin-5-yl]-3-hydroxy-5-oxo-hept-6-enoic acid methyl ester;
    5-Oxorosuvastatin methyl ester;
    ZD-6;
    (3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester;
    Methyl (+)-(3R)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-(N-Methyl-NMethansulphonylaMino) pyriMidin-5-yl]-3-hydroxy-5-oxo- 6(E)-heptenoate;
    methyl (3R,6E)-7-[4-(4-flurophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)mino]-5-pyrimidyl]-3-hydroxy-5-oxo-6-heptenoate;

    CAS No. 147118-39-6
    Molecular Formula C23H28FN3O6S
    Molecular Weight 493.54800
    PSA 135.14000
    LogP 3.77910

    Properties

    Density 1.311g/cm3
    Boiling Point 701.7ºC at 760 mmHg
    Flash Point 378.2ºC
    Refractive Index 1.569
    Vapor Pressure 1.15E-20mmHg at 25°C

    Synthesis Route

    7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester→7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
    Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate+N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide→7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
    3-(tert-Butyldimethylsilyloxy)glutaric anhydride→7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester

    Precursor

    4-Fluorobenzaldehyde
    Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
    3-(tert-Butyldimethylsilyloxy)glutaric anhydride
    N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide

    Downstream Product

    methyl (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
    Rosuvastatin

Популярные теги: 7-[4-fluorophenyl]-6-isopropyl)-2-(n-methyl-n-methylsulfonyl amino)pyrimidine-5-yl]-(3r)-3-(terbutyldimethylsilyloxy)-5-oxo-6e-heptane acid,methyl ester, Китай, производитель, поставщик, фабрика, оптовая торговля, низкая цена, высокое качество
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