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5-(hydroxymethyl)cytosine

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Origin: China

Cas No: 1123-95-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 1123-95-1 Formula: C5H7N3O2 Molecular Weight: 141.12800

Description

5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952. However, in 2009 it was found to be abundant in human and mouse brains, as well as in embryonic stem cells. In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. Its molecular formula is C5H7N3O2.

Basic Info

Chemical Name	5-(hydroxymethyl)cytosine
Synonyms	5-Hydroxymethylcytosine; 6-amino-5-(hydroxymethyl)-1H-pyrimidin-2-one; 4-AMINO-2-HYDROXY-5-(HYDROXYMETHYL)PYRIMIDINE; 2(1H)-Pyrimidinone, 4-amino-5-(hydroxymethyl)-;
CAS No.	1123-95-1
Molecular Formula	C5H7N3O2
Molecular Weight	141.12800
PSA	92.26000
LogP	-0.16210

Properties

Density	1.65g/cm3
Refractive Index	1.696

Safety Info

HS Code	2933990090
Hazard Codes	Xi

Synthesis Route

5-methyl-2'-deoxycytidine→5-methylcytosine+5-(hydroxymethyl)cytosine
5-methylcytidine→5-methylcytosine+5-(hydroxymethyl)cytosine
2(1H)-Pyrimidinone, 4-amino-1-(4-((2-amino-3-hydroxy-1-oxopropyl)amino)-9-((aminoiminomethyl)amino)-6-C-carboxy-2,3,4,7,9-pentadeoxy-α-L-talo-non-2-enopyranosyl)-5-(hydroxymethyl)-, (S)-→5-(hydroxymethyl)cytosine+L-serine

Precursor

5-methylcytosine
5-methylcytidine
5-methyl-2'-deoxycytidine
Formaldehyde

Downstream Product

(6-amino-2-oxo-1H-pyrimidin-5-yl)methanesulfonic acid

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