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4-(trifluoromethyl)-1,3-thiazol-2-amine

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Origin: China

Cas No: 349-49-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 349-49-5 Formula: C4H3F3N2S Molecular Weight: 168.14000

Description

4-(Trifluoromethyl)-2-thiazolamine can be used to prepare phenethylthiazolylthiourea analogs as HIV-1 reverse transcriptase inhibitors. 4-(Trifluoromethyl)-2-thiazolamine can also be used to synthesize 2-amino benzamide derivatives as allosteric glucokinase activators.

Basic Info

Chemical Name	4-(trifluoromethyl)-1,3-thiazol-2-amine
Synonyms	4-(trifluoromethyl)-1,3-thiazole-2-amine; 2-Amino-4-trifluoromethyl-1,3-thiazole; 4-(Trifluoromethyl)thiazol-2-amine; 2-Amino-4-(trifluoromethyl)-1,3-thiazole; 2-Amino-4-trifluoromethylthiazole; 2-Amino-4-trifluoromethylthiazole hydrobromide; 2-amino-4-(trifluoromethyl)thiazole; 4-Trifluormethyl-thiazol-2-ylamin; 4-(Trifluoromethyl)-2-thiazolamine; 4-trifluoromethyl-thiazol-2-ylamine; 4-Trifluoromethyl-thiazole-2ylamine;
CAS No.	349-49-5
Molecular Formula	C4H3F3N2S
Molecular Weight	168.14000
PSA	67.15000
LogP	2.32530

Properties

Density	1.557g/cm3
Boiling Point	214ºC at 760mmHg
Melting Point	60-62ºC
Flash Point	83.2ºC
Refractive Index	1.503

Safety Info

Safety Statements	S26; S36/37/39
HS Code	2934100090
Risk Statements	R20/21/22
Hazard Codes	Xi

Synthesis Route

3-Bromo-1,1,1-trifluoroacetone+thiourea→4-(trifluoromethyl)-1,3-thiazol-2-amine
→4-(trifluoromethyl)-1,3-thiazol-2-amine
+thiourea→4-(trifluoromethyl)-1,3-thiazol-2-amine

Precursor

3-chloro-1,1,1-trifluoropropan-2-one
thiourea

3-Bromo-1,1,1-trifluoroacetone

Downstream Product

5-Bromo-4-(trifluoromethyl)thiazol-2-amine
2-Bromo-4-(trifluoromethyl)thiazole
phenyl N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]carbamate
N-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]acetamide

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