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4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid

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Origin: China

Cas No: 55837-27-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 55837-27-9 Formula: C17H18N2O5S Molecular Weight: 362.40000

Description

High-ceiling loop diuretic; structurally related to Bumetanide. Diuretic.

Basic Info

Chemical Name	4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid
Synonyms	Tauliz; Piretanido [Spanish]; Piretanido [INN-Spanish]; Hoe-118; Piretanidum [INN-Latin]; 4-phenoxy-3(1-pyrrolidinyl)-5-sulfamoylbenzoic acid; 4-phenoxy-3-(pyrrolidin-1-yl)-5-sulfamoylbenzoic acid; Arelix (TN); piretanide; 3-(1-pyrrolidinyl)-4-phenoxy-5-sulfamylbenzoic acid;
CAS No.	55837-27-9
Molecular Formula	C17H18N2O5S
Molecular Weight	362.40000
PSA	118.31000
LogP	4.27080

Properties

Appearance & Physical State	Pale yellow powder.
Density	1.415 g/cm3
Boiling Point	597.7ºC at 760 mmHg
Flash Point	315.3ºC
Refractive Index	1.64

Safety Info

HS Code	2935009090

Synthesis Route

1,4-Dibromobutane+methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate→4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid
1,4-Dibromobutane+5-amino-3-(dimethylaminomethylenesulfamoyl)- 4-phenoxybenzoic acid methyl ester→4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid

Precursor

1,4-Dibromobutane
5-amino-3-(dimethylaminomethylenesulfamoyl)- 4-phenoxybenzoic acid methyl ester
methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate

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