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4'-(Methylsulfonyl)acetophenone

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Origin: China

Cas No: 10297-73-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 10297-73-1 Formula: C9H10O3S Molecular Weight: 198.23900

Description

4-(Methylsulfonyl)acetophenone is an impurity of Etoricoxib, which is a specific inhibitor of COX-2.

Basic Info

Chemical Name	4'-(Methylsulfonyl)acetophenone
Synonyms	4-Methylsulphonylacetophenone; 4-(Methylsulfonyl)Acetophenone; 1-(4-methylsulfonylphenyl)ethanone;
CAS No.	10297-73-1
Molecular Formula	C9H10O3S
Molecular Weight	198.23900
PSA	59.59000
LogP	2.37350

Properties

Appearance & Physical State	White to slightly yellow cryst. powder or needles
Density	1.218 g/cm3
Boiling Point	385.4ºC at 760 mmHg
Melting Point	129-131ºC
Flash Point	242ºC
Refractive Index	1.521
Stability	Stable under normal temperatures and pressures.
Storage Condition	Store in a cool, dry place. Keep container closed when not in use.
Vapor Pressure	3.82E-06mmHg at 25°C

Safety Info

Safety Statements	S24/25
HS Code	2914700090
WGK Germany	3
Hazard Codes	Xi

Synthesis Route

1-(4-(methylsulfonyl)phenyl)ethan-1-ol→4'-(Methylsulfonyl)acetophenone+4-Methylsulphonylbenzoic acid
1-(4-methylsulfanylphenyl)ethanone→4'-(Methylsulfonyl)acetophenone
4'-Iodoacetophenone+sodium,methanesulfinate→4'-(Methylsulfonyl)acetophenone

Precursor

1-(4-methylsulfanylphenyl)ethanone
1-(4-(methylsulfonyl)phenyl)ethan-1-ol
dichloromethane
4'-Iodoacetophenone

Downstream Product

4-(Methylsulfonyl)phenylacetic acid
[2-(4-methylsulfonylphenyl)-2-oxoethyl] 2-phenylacetate
rofecoxib
2-Bromo-1-[4-(methylsulfonyl)phenyl]-1-ethanone

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