Welcome to GlobalChemMall

ALL CATEGORIES
Categories
0
Wishlist
Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 4-aminofolic acid
Picture of 4-aminofolic acid

4-aminofolic acid

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 54-62-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

  • Products Specification
  • Product Description

  • Property

    CAS No.: 54-62-6 Formula: C19H20N8O5 Molecular Weight: 440.41300

    Description

    Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.
    It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.

    Basic Info

    Chemical Name 4-aminofolic acid
    Synonyms

    Aminoperin;
    pteramina;
    AGPA;
    Aminopterin;
    Minopterin;
    apga;
    aminopteridin;

    CAS No. 54-62-6
    Molecular Formula C19H20N8O5
    Molecular Weight 440.41300
    PSA 219.33000
    LogP 1.87040

    Properties

    Appearance & Physical State Yellow solid.
    Density 1.588g/cm3
    Melting Point 228-235ºC (dec.)
    Refractive Index 1.761
    Stability Stable at normal temperatures and pressures.
    Storage Condition 2-8ºC

    Safety Info

    RTECS MA1050000
    Hazard Class 6.1(a)
    Safety Statements S53-S28-S36/37-S45
    HS Code 3822009000
    WGK Germany 3
    Packing Group I
    RIDADR UN 2811
    Risk Statements R61; R28
    Hazard Codes T+
    Hazard Declaration H300; H360
    Symbol GHS06, GHS08
    Signal Word Danger
    Caution Statement P201; P264; P301 + P310; P308 + P313

    Synthesis Route

    6-(bromomethyl)pteridine-2,4-diamine+N-(4-aminobenzoyl)-L-glutamic acid→4-aminofolic acid
    Folic acid→4-aminofolic acid
    N-(4-aminobenzoyl)-L-glutamic acid+Water→4-aminofolic acid

    Precursor

    6-Bromomethyl-pteridine-2,4-diamineHBr
    N-(4-aminobenzoyl)-L-glutamic acid
    Water
    6-(bromomethyl)pteridine-2,4-diamine

    Downstream Product

    dimethyl 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-(trideuteriomethyl)amino]benzoyl]amino]pentanedioate
    4-[[2-(2,4-diaminopteridin-6-yl)acetyl]amino]benzoic acid
    4-[(2,4-diaminopteridin-6-yl)methylamino]benzoic acid
    METHOTREXATE-D3

Hot tags: 4-aminofolic acid, China, manufacturers, suppliers, factory, wholesale, low price, high quality
You may also like