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4-aminoantipyrine

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Origin: China

Cas No: 83-07-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
83-07-8
Other Names:
4-Aminoantipyrine
MF:
C11H13N3O
EINECS No.:
201-452-3
Place of Origin:
Hubei, China
Type:
Pharmaceutical Intermediates
Purity:
99%min
Brand Name:
Fortunachem
Model Number:
Fortuna
Application:
As medical Intermediates
Appearance:
white powder, yellow powder
Melting point:
105-110 °C
Packaging&Delivery
Packaging Details
4-Aminoantipyrine CAS 83-07-8
10g/bag,100g/bag,500g/bag,1kg/bag
Port
Any port in China

Property

CAS No.: 83-07-8 Formula: C11H13N3O Molecular Weight: 203.24000

Description

Ampyrone is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. Due to the risk of agranulocytosis its use as a drug is discouraged. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates liver microsomes and is also used to measure extracellular water.

Basic Info

Chemical Name	4-aminoantipyrine
Synonyms	4-amino-1,5-dimethyl-2-phenylpyrazol-3-one; 3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-; 4-Aminoantipyrine;
CAS No.	83-07-8
Molecular Formula	C11H13N3O
Molecular Weight	203.24000
PSA	52.95000
LogP	1.64780

Properties

Appearance & Physical State	Pale yellow crystals
Density	0.8
Boiling Point	340ºC
Melting Point	105-110ºC
Refractive Index	1.606
Water Solubility	ca. 500 g/L (20 ºC)
Stability	Stable. May be light sensitive.
Storage Condition	Store at RT.

Safety Info

RTECS	CD2480000
Safety Statements	S26-S36/37/39
HS Code	29331190
WGK Germany	3
Risk Statements	R22; R36/37/38
Hazard Codes	Xn
Hazard Declaration	H302
Signal Word	Warning
Caution Statement	P301 + P312 + P330
Symbol	GHS07

Synthesis Route

Aminophenazone→4-aminoantipyrine+1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one
Aminophenazone→4-aminoantipyrine+1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one
Metamizole sodium→4-aminoantipyrine+1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	SPB-1	250.	1957.	isothermal
Other	Methyl Silicone	-	1950.	custom temperature program

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	1700 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	1200 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	800 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

antipyrine
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)benzamide
Aminophenazone
1,5-dimethyl-4-nitroso-2-phenylpyrazol-3-one

Downstream Product

N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)pyridine-3-carboxamide
1,5-dimethyl-2-phenyl-4-(propan-2-ylamino)pyrazol-3-one
1,3-bis(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)thiourea
2-PHENYL-2-PROPANOL

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