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4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

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Origin: China

Cas No: 152121-47-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
152121-47-6
Other Names:
SB203580
MF:
C21H16FN3OS
EINECS No.:
/
Place of Origin:
Hubei China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
HHD
Model Number:
HHD-152121-47-6
Purity:
98%
Appearance:
Off-white Powder
Molecular Weight:
377.43
Sample:
Available
COA:
Available
Solubility:
DMSO: ≥ 33 mg/mL
Packaging&Delivery
Packaging Details
on require
Port
Wuhan/SH/Shenzhen
Lead Time:
Quantity(Grams) 1 - 50 >50
Est. Time(days) 7 To be negotiated
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Property

CAS No.: 152121-47-6 Formula: C21H16FN3OS Molecular Weight: 377.43500

Description

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity.

Basic Info

Chemical Name	4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
Synonyms	PB 203580; 4-(4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(pyridin-4-yl)-1H-imidazole; RWJ 64809; Pyridine,4-(5-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl); 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(pyridin-4-yl)imidazole; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;
CAS No.	152121-47-6
Molecular Formula	C21H16FN3OS
Molecular Weight	377.43500
PSA	77.85000
LogP	5.54790

Properties

Appearance & Physical State	White solid
Density	1.42 g/cm3
Boiling Point	615.6ºC at 760 mmHg
Melting Point	249 - 250ºC
Flash Point	326.1ºC
Refractive Index	1.714
Vapor Pressure	2E-14mmHg at 25°C

Safety Info

Safety Statements	26-39
HS Code	2818200000
Risk Statements	R22; R41
Hazard Codes	Xn
Signal Word	Danger
Symbol	GHS05, GHS07
Caution Statement	P280; P305 + P351 + P338
Hazard Declaration	H302; H318

Synthesis Route

4-[4-(4-fluorophenyl)-2-(4-methylsulfanylphenyl)-1H-imidazol-5-yl]pyridine→4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
4-Pyridinemethanol→4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
4-Fluorobenzoyl chloride→4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Precursor

4-Pyridinemethanol
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine
4-[4-(4-fluorophenyl)-2-(4-methylsulfanylphenyl)-1H-imidazol-5-yl]pyridine
4-Fluoro-N-Methoxy-N-Methylbenzamide

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