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(3S,4R)-4-(4-Fluorophenyl)-3-Hydroxymethyl-1-Methylpiperidine

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начало: Китай

Кас Но: 105812-81-5

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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Характеристики продукции
Описание продукта

Quick Details
CAS No.:
105812-81-5
Other Names:
(-)-Trans-paroxol
MF:
C13H18FNO
EINECS No.:
406-030-4
Place of Origin:
Shandong, China
Type:
Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
99%min
Brand Name:
ench
Model Number:
ench-105812-81-5
Application:
Pharm Intermediates, Fine Chemical Intermediate
Appearance:
White Powder, white powder
Product Name:
(-)-Trans-paroxol
Grade:
pham Grade
Assay:
99%min
Shelf life:
2 Years
melting point:
97-101 °C
MW::
223.29
density:
n/a
Boiling point:
n/a
Packaging&Delivery
Packaging Details
1kg / bag, aluminum foil bag, 25kg / barrel, or as your demand.
Port
China main ports

Property

CAS No.: 105812-81-5 Formula: C13H18FNO Molecular Weight: 223.28700

Description

An intermediate in the synthesis of Paroxetine, a selective serotonin reuptake inhibitor.

Basic Info

Chemical Name	(3S,4R)-4-(4-Fluorophenyl)-3-Hydroxymethyl-1-Methylpiperidine
Synonyms	(3S,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol; (3S,4R)-4-(4′-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine; (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine;
CAS No.	105812-81-5
Molecular Formula	C13H18FNO
Molecular Weight	223.28700
PSA	23.47000
LogP	1.79120

Properties

Appearance & Physical State	white to light yellow crystal powder
Density	1.092g/cm3
Boiling Point	300.3ºC at 760mmHg
Melting Point	97-101ºC
Flash Point	135.4ºC
Refractive Index	1.518
Vapor Pressure	0.000504mmHg at 25°C

Safety Info

Hazard Class	9
Safety Statements	S22-S26-S39-S61
HS Code	2933399090
Packing Group	III
RIDADR	UN3077
Risk Statements	R22; R41; R51/53
Hazard Codes	Xn

Synthesis Route

(-)-(3S,4R)-4-(4-fluoro-phenyl)-1-methyl-piperidine-3-carboxylic acid methyl ester→(3S,4R)-4-(4-Fluorophenyl)-3-Hydroxymethyl-1-Methylpiperidine
(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione→(3S,4R)-4-(4-Fluorophenyl)-3-Hydroxymethyl-1-Methylpiperidine
(+/-)-trans-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-piperidine-3-carboxylic acid ethyl ester→(3S,4R)-4-(4-Fluorophenyl)-3-Hydroxymethyl-1-Methylpiperidine

Precursor

4-Fluorocinnamic acid
(+/-)-trans-4-(4-fluorophenyl)-1-methyl-2,6-dioxo-piperidine-3-carboxylic acid ethyl ester
(-)-(3S,4R)-4-(4-fluoro-phenyl)-1-methyl-piperidine-3-carboxylic acid methyl ester
(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Downstream Product

[(3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl]methyl methanesulfonate
Paroxetine
(3S,4R)-4-(4-fluorophenyl)-3-[(3-methoxy-4-phenylmethoxyphenoxy)methyl]-1-methylpiperidine
Paroxol Tosylate

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