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Picture of (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate

(3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate

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Origin: China

Cas No: 1201913-82-7

Specification: 99%min

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    CAS No.: 1201913-82-7 Formula: C22H28O7 Molecular Weight: 404.45400

    Description

    Tofogliflozin (USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi. It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. As of September 2012[update], the drug is in Phase III clinical trials.

    Basic Info

    Chemical Name (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate
    Synonyms

    Tofogliflozin [USAN:INN];
    UNII-P8DD8KX4O4;
    (1S,3'R,4'S,5'S,6'R)-6-((4-Ethylphenyl)methyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro(2-benzofuran-1,2'-pyran)-3',4',5'-triol monohydrate;
    (1S,3'R,4'S,5'S,6'R)-6-((4-Ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol monohydrate;
    Tofogliflozin hydrate (JAN);
    Tofogliflozin (USAN);
    CSG452;

    CAS No. 1201913-82-7
    Molecular Formula C22H28O7
    Molecular Weight 404.45400
    PSA 108.61000
    LogP 0.93230

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