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(3-hydroxy-2-phenylpropyl) carbamate

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Origin: China

Cas No: 25451-53-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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Product Description

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CAS No.: 25451-53-0 Formula: C10H13NO3 Molecular Weight: 195.21500

Description

Hydroxy-2-phenylpropyl Carbamate is an impurity in the synthesis of Felbamate, an antiepileptic, structurally similar to meprobamate.

Basic Info

Chemical Name	(3-hydroxy-2-phenylpropyl) carbamate
Synonyms	3-hydroxy-2-phenylpropyl aminooate; W 873; 3-hydroxy-2-phenylpropyl carbamate; monocarbamate felbamate; 2-Phenyl-3-hydroxypropyl carbamate; 2-phenyl-1,3-propanediol monocarbamate; 1,3-Propanediol,2-phenyl-,monocarbamate; 2-Phenyl-3-carbamoyloxy-propanol-(1);
CAS No.	25451-53-0
Molecular Formula	C10H13NO3
Molecular Weight	195.21500
PSA	73.54000
LogP	1.37160

Properties

Density	1.214g/cm3
Boiling Point	415.1ºC at 760mmHg
Flash Point	204.8ºC
Refractive Index	1.559
Vapor Pressure	1.24E-07mmHg at 25°C

Synthesis Route

2-Phenyl-1,3-propanediol+N,N'-Carbonyldiimidazole→(3-hydroxy-2-phenylpropyl) carbamate
2-phenyl-3-methoxy-propanol carbamate→(3-hydroxy-2-phenylpropyl) carbamate
2-Phenyl-1,3-propanediol→(3-hydroxy-2-phenylpropyl) carbamate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	>420 mg/kg	1.Autonomic Nervous System-smooth muscle relaxant (mechanism undefined, spasmolytic)