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3-Bromo-2-fluorobenzoic acid

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Origin: China

Cas No: 161957-56-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 161957-56-8 Formula: C7H4BrFO2 Molecular Weight: 219.00800

Description

3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).

Basic Info

Chemical Name	3-Bromo-2-fluorobenzoic acid
Synonyms	2-fluoro-3-bromobenzoic acid; 3-Bromo-2-fluoro-benzoic acid; 3-Bromo-2-Fluorobenzoic acid;
CAS No.	161957-56-8
Molecular Formula	C7H4BrFO2
Molecular Weight	219.00800
PSA	37.30000
LogP	2.28640

Properties

Melting Point	168 °C

Safety Info

HS Code	2916399090
Hazard Codes	Xi

Synthesis Route

2-Bromofluorobenzene+carbon dioxide→3-Bromo-2-fluorobenzoic acid
2-Bromofluorobenzene+butyllithium→3-Bromo-2-fluorobenzoic acid
carbon dioxide→3-Bromo-2-fluorobenzoic acid

Precursor

carbon dioxide
butyllithium
2-Bromofluorobenzene

Downstream Product

Methyl 3-amino-2-fluorobenzoate
methyl 3-bromo-2-fluorobenzoate
Ethyl 3-bromo-2-fluorobenzoate
dabrafenib

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