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2-Chloro-4-fluorobenzoic acid

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Origin: China

Cas No: 2252-51-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
2252-51-9
Other Names:
Benzoic acid, 2-chloro-4-fluoro
MF:
C7H4ClFO2
EINECS No.:
218-845-0
Type:
Agrochemical Intermediates, Pharmaceutical Intermediates
Purity:
99%
Brand Name:
Richest
Model Number:
Richest
Application:
phamaceutical intermediates
Appearance:
White crystalline powder
Other Country:
china
Packaging&Delivery
Packaging Details
1kg/bag,25kg/bag,25kg/drum or customer's request
Port
shanghai
Lead Time:
Quantity(Kilograms) 1 - 25 >25
Est. Time(days) 3 To be negotiated

Property

CAS No.: 2252-51-9 Formula: C7H4ClFO2 Molecular Weight: 174.55700

Description

2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.

Basic Info

Chemical Name	2-Chloro-4-fluorobenzoic acid
Synonyms	Benzoic acid,2-chloro-4-fluoro; 2-Cl-4-FHBA; 2-choro-4-fluorobenzoic acid; 2-Chlor-4-fluor-benzoesaeure; 2-chloro-4-fluoro-benzoic acid; 4-fluoro-2-chloro-benzoic acid;
CAS No.	2252-51-9
Molecular Formula	C7H4ClFO2
Molecular Weight	174.55700
PSA	37.30000
LogP	2.17730

Properties

Appearance & Physical State	white powder or flakes
Density	1.477 g/cm3
Boiling Point	271.9ºC at 760 mmHg
Melting Point	183-186ºC
Flash Point	118.2ºC
Vapor Pressure	0.00308mmHg at 25°C

Safety Info

Safety Statements	S26-S37/39
HS Code	2916399090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi
Hazard Declaration	H302; H315; H318; H335
Signal Word	Danger
Symbol	GHS05, GHS07
Caution Statement	P261; P280; P305 + P351 + P338

Synthesis Route

2-Chloro-4-fluorotoluene→2-Chloro-4-fluorobenzoic acid
1-Chloro-3-fluorobenzene→2-Chloro-4-fluorobenzoic acid
2'-Chloro-4'-fluoroacetophenone→2-Chloro-4-fluorobenzoic acid

Precursor

2-Chloro-4-fluorotoluene
1-Chloro-3-fluorobenzene
2'-Chloro-4'-fluoroacetophenone

Downstream Product

4-fluorobenzoic acid
Methyl 2-Chloro-4-fluorobenzoate
1-Chloro-3-fluorobenzene
2-Chloro-4-fluorobenzoyl chloride

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