Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> (2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one,hydrochloride

(2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one,hydrochloride

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Origin: China

Cas No: 75472-91-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

Property

CAS No.: 75472-91-2 Formula: C20H25ClN2O3S Molecular Weight: 408.94200

Description

Desacetyl Diltiazem Hydrochloride is a metabolite of Diltiazem Hydrochloride, a calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).

Basic Info

Chemical Name	(2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one,hydrochloride
Synonyms	EINECS 278-217-7; (2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride; (2S-cis)-5-(2-(Dimethylamino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride;
CAS No.	75472-91-2
Molecular Formula	C20H25ClN2O3S
Molecular Weight	408.94200
PSA	78.31000
LogP	3.66470

Properties

Boiling Point	616ºC at 760 mmHg
Flash Point	326.4ºC

Synthesis Route

(E)-1-(4-methoxyphenyl)-4,4-dimethylpent-1-en-3-one→(2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one,hydrochloride
Anisic aldehyde→(2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one,hydrochloride
tert-butyl (2R,3S)-3-(4-methoxyphenyl)glycidate→(2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one,hydrochloride

Precursor

tert-butyl (2R,3S)-3-(4-methoxyphenyl)glycidate
1-[(2R,3S)-3-(4-methoxyphenyl)oxiran-2-yl]-2,2-dimethylpropan-1-one
(E)-1-(4-methoxyphenyl)-4,4-dimethylpent-1-en-3-one
Anisic aldehyde

Downstream Product

diltiazem hydrochloride

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