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(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

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Origin: China

Cas No: 327623-37-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 327623-37-0 Formula: C20H18F7NO2 Molecular Weight: 437.35100

Basic Info

Chemical Name	(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
Synonyms	QC-634; (2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine; (2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine; 2s,3r------s; (2R,3S)-2-{(1R)-1-[3,5-bis-trifluoromethylphenyl]ethoxy}-3-(4-fluorophenyl)morpholine;
CAS No.	327623-37-0
Molecular Formula	C20H18F7NO2
Molecular Weight	437.35100
PSA	30.49000
LogP	5.95690

Synthesis Route

6-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine→(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine+(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
(2S,3R)-2-((1-(3,5-bis(trifluoromethyl)phenyl)vinyl)oxy)-3-(4-fluorophenyl)-4-((R)-1-phenylethyl)morpholine→(2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine+(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
(2S,3R)-3-(4-fluorophenyl)-4-((R)-1-phenylethyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate→(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

Precursor

4-Fluoroacetophenone
(2S,3R)-2-((1-(3,5-bis(trifluoromethyl)phenyl)vinyl)oxy)-3-(4-fluorophenyl)-4-((R)-1-phenylethyl)morpholine
(2S,3R)-3-(4-fluorophenyl)-4-((R)-1-phenylethyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate
6-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine

Downstream Product

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one

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