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(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide

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Origin: China

Cas No: 133865-89-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
133865-89-1
Other Names:
Safinamide powder
MF:
C17H19FN2O2
EINECS No.:
NA
Place of Origin:
Beijing, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade, Tech Grade
Brand Name:
Yibai
Model Number:
133865-89-1
Purity:
98.0~102.0%
Product Name:
SAFINAMIDE
Appearance:
white to off white powder
COA:
avaliable
Assay:
98.0~102.0%
resudue on igniton:
0.5%
Shelf life:
3 Years
Total Impurities:
≤1.0%
Quality:
USP
Grade:
Phamaceutical Grade
Production Capacity:
50kg/month
Packaging&Delivery
Packaging Details
Bulk qty: 25kg/drum, inside two level plastic bags
Small qty: Aluminium bag, inside two level plastic bags
Others: can do your package or split small packages according to your request
Port
Beijing, Shanghai, Shenzhen
Lead Time:
Quantity(Grams) 1 - 1000 >1000
Est. Time(days) 4 To be negotiated

Property

CAS No.: 133865-89-1 Formula: C17H19FN2O2 Molecular Weight: 302.34300

Description

Safinamide (INN; brand name Xadago, former developmental code name EMD-1195686) is a drug indicated for the treatment of Parkinson's disease with multiple methods of action. In 2007, a Phase III clinical trial was started. It was scheduled to run until 2011. The compound was originally discovered at Farmitalia-Carlo Erba, first published in 1998 and developed by Newron Pharmaceuticals, which sold the rights to Merck-Serono in 2006. In October 2011 Merck-Serono announced that they would give all rights to develop the compound back to Newron.
Potential additional uses might be restless legs syndrome (RLS) and epilepsy. They were being tested in Phase II trials in 2008, but no results are available.

Basic Info

Chemical Name	(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide
Synonyms	(S)-(+)-2-[4-(3-fluorobenzyloxy)benzylamino]-propanamide; (2S)-2-[4-(3-fluorobenzyloxy)benzylamino]propionamide; Safinamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propionamide;
CAS No.	133865-89-1
Molecular Formula	C17H19FN2O2
Molecular Weight	302.34300
PSA	64.35000
LogP	3.45930

Properties

Density	1.189 g/cm3
Boiling Point	476.7ºC at 760 mmHg
Refractive Index	1.569
Vapor Pressure	2.98E-09mmHg at 25°C

Synthesis Route

4-[(3-fluorophenyl)methoxy]benzaldehyde+(2S)-2-aminopropanamide,hydrochloride→(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide
(S)-2-[4-(3-fluorobenzyloxy)benzylideneamino]propanamide→(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide
L-alaninamide+4-[(3-fluorophenyl)methoxy]benzaldehyde→(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide

Precursor

(S)-2-[4-(3-fluorobenzyloxy)benzylideneamino]propanamide
4-[(3-fluorophenyl)methoxy]benzaldehyde
2-Aminopropanamide hydrochloride
(2S)-2-aminopropanamide,hydrochloride

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