Главная > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

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начало: Китай

Кас Но: 874638-80-9

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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Характеристики продукции
Описание продукта

Quick Details
CAS No.:
874638-80-9
MF:
C20H17FO6
EINECS No.:
618-021-4
Place of Origin:
China
Type:
Syntheses Material Intermediates
Purity:
99%
Brand Name:
Zichang
Model Number:
874638-80-9
Application:
pharmaceutical industry
Appearance:
white powder
Molecular Weight:
372.34
Melting point:
133℃
Boiling point:
458.6±34.0 °C
Density:
1.333 G/mL
Package:
25kg/bag/drum
Storage:
Dry Storage
Certification:
ISO9001
COA:
Availale
Sample:
Availiable
Color:
White
Packaging&Delivery
Packaging Details
if order 1-20kg, aluminum foil bag+carton box.
If order is more than 20kg,plastic bag+25kg carton drum
Port
shanghai /qingdao /tianjin
Lead Time:
Quantity(Grams) 1 - 500 >500
Est. Time(days) 5 To be negotiated

Property

CAS No.: 874638-80-9 Formula: C20H17FO6 Molecular Weight: 372.34400

Description

(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic Acid γ-Lactone 3,5-Dibenzoate is a reactant used in the synthesis of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

Basic Info

Chemical Name	((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
Synonyms	[(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate;
CAS No.	874638-80-9
Molecular Formula	C20H17FO6
Molecular Weight	372.34400
PSA	78.90000
LogP	2.72260

Synthesis Route

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one+Benzoyl chloride→((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
ethyl (2S,3R)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,3-dihydroxy-2-methylpropanoate→((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
(3R)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate→((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

Precursor

Benzoyl chloride
(3R)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one
ethyl (2S,3R)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,3-dihydroxy-2-methylpropanoate

Downstream Product

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate

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