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Picture of ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

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Origin: China

CasNo: 874638-80-9

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Description
  • Quick Details

    CAS No.:
    874638-80-9
    MF:
    C20H17FO6
    EINECS No.:
    618-021-4
    Place of Origin:
    China
    Type:
    Syntheses Material Intermediates
    Purity:
    99%
    Brand Name:
    Zichang
    Model Number:
    874638-80-9
    Application:
    pharmaceutical industry
    Appearance:
    white powder
    Molecular Weight:
    372.34
    Melting point:
    133℃
    Boiling point:
    458.6±34.0 °C
    Density:
    1.333 G/mL
    Package:
    25kg/bag/drum
    Storage:
    Dry Storage
    Certification:
    ISO9001
    COA:
    Availale
    Sample:
    Availiable
    Color:
    White

    Packaging&Delivery

    Packaging Details
    if order 1-20kg, aluminum foil bag+carton box.
    If order is more than 20kg,plastic bag+25kg carton drum
    Port
    shanghai /qingdao /tianjin
    Lead Time:
    Quantity(Grams)1 - 500>500
    Est. Time(days)5To be negotiated
  •  

    Property

    CAS No.: 874638-80-9 Formula: C20H17FO6 Molecular Weight: 372.34400
     

    Description

    (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic Acid γ-Lactone 3,5-Dibenzoate is a reactant used in the synthesis of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
     

    Basic Info

    Chemical Name ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
    Synonyms

    [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate;

    CAS No. 874638-80-9
    Molecular Formula C20H17FO6
    Molecular Weight 372.34400
    PSA 78.90000
    LogP 2.72260
     

    Synthesis Route

    (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one+Benzoyl chloride→((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
    ethyl (2S,3R)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,3-dihydroxy-2-methylpropanoate→((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
    (3R)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate→((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
     

    Precursor

    Benzoyl chloride
    (3R)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate
    (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one
    ethyl (2S,3R)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,3-dihydroxy-2-methylpropanoate
     

    Downstream Product

    (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate

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