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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> (2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
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(2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

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Origin: China

Cas No: 81024-43-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 81024-43-3 Formula: C15H25NO3 Molecular Weight: 267.36400

    Description

    (R)-Enantiomer of Metoprolol. Antihypertensive; antianginal; antiarrhythmic (class II).

    Basic Info

    Chemical Name (2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    Synonyms

    BIDD:GT0581;
    (2R)-metoprolol;
    (+)-Metoprolol;
    d-Metoprolol;
    (R)-metoprolol;
    (R)-1-isopropylamino-3-[4-(2-metoxyethyl)phenoxy]propan-2-ol;

    CAS No. 81024-43-3
    Molecular Formula C15H25NO3
    Molecular Weight 267.36400
    PSA 50.72000
    LogP 2.00410

    Properties

    Density 1.033g/cm3
    Boiling Point 398.6ºC at 760 mmHg
    Melting Point 39-42ºC
    Flash Point 194.9ºC
    Refractive Index 1.507
    Storage Condition -20ºC Freezer, Under Inert Atmosphere

    Synthesis Route

    Metoprolol→(2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol+(2S)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    isopropylamine+(2S)-2-[[4-(2-methoxyethyl)phenoxy]methyl]oxirane→(2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol+(2S)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    isopropylamine+(R)-3-[4-(2-Methoxyethyl)phenoxy]-1,2-epoxypropane→(2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol+(2S)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

    Precursor

    (R)-3-[4-(2-Methoxyethyl)phenoxy]-1,2-epoxypropane
    isopropylamine
    (2S)-2-[[4-(2-methoxyethyl)phenoxy]methyl]oxirane
    2-[[4-(2-methoxyethyl)phenoxy]methyl]oxirane

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