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2'-O-methylcytidine

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Origin: China

Cas No: 2140-72-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 2140-72-9 Formula: C10H15N3O5 Molecular Weight: 257.24300

Description

Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Basic Info

Chemical Name	2'-O-methylcytidine
Synonyms	2'-OMe Cytidine; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one; 2'-OMeCytidine; 2'-O-Methyl-D-cytidine; 2’-O-Methyl Cytidine; O2'-methylcytidine; 4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one; 2'-OMe-C; 2'-O-methyl-2'-deoxy-cytidine; 2&#39-O-Methylcytidine; 2'-O-Methylcytidine; 2'-O-methyl-cytidine; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one; 2'-O-(TERT-BUTYLDIMETHYLSILYL)-6A-HYDROXY-7-EPI-PACLITAXEL;
CAS No.	2140-72-9
Molecular Formula	C10H15N3O5
Molecular Weight	257.24300
PSA	119.83000
LogP	-1.32770

Properties

Density	1.68 g/cm3
Boiling Point	506ºC at 760 mmHg
Melting Point	252-253ºC
Flash Point	259.8ºC
Refractive Index	1.677
Storage Condition	-20ºC

Safety Info

Safety Statements	S26; S36
HS Code	2934999090
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

TRIMETHYLSULFONIUM HYDROXIDE+cytidine→4-amino-1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidin-2-one+2'-O-methylcytidine
trimethylphenylammonium hydroxide+cytidine→N-3-Methyluridine+4-amino-1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidin-2-one
TRIMETHYLSULFONIUM HYDROXIDE+cytidine→4-amino-1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidin-2-one+2'-O-methylcytidine

Precursor

N4-benzoyl-3',5'-di-O-benzoyl-2'-O-methylcytidine
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine
cytidine
TRIMETHYLSULFONIUM HYDROXIDE

Downstream Product

N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
N4-Benzoyl-2'-O-methylcytidine

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