Home > Aminoacid Compounds> 2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

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Origin: China

Cas No: 531-76-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 531-76-0 Formula: C13H18Cl2N2O2 Molecular Weight: 305.20000

Basic Info

Chemical Name	2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
Synonyms	D-Sarcolysin; Sarcoclorin; Sarkolysin; Merphalan; Merfalan; Sarcolysin; Sarcolysinum; D-Sarcolysine; Mephalan; Medfalan; Sarcolysine;
CAS No.	531-76-0
Molecular Formula	C13H18Cl2N2O2
Molecular Weight	305.20000
PSA	66.56000
LogP	2.62530

Properties

Density	1.32g/cm3
Boiling Point	473.1ºC at 760mmHg
Melting Point	182-183ºC (decomp)
Flash Point	239.9ºC

Safety Info

HS Code	2922499990

Synthesis Route

methyl 2-benzamido-3-[4-[bis(2-hydroxyethyl)amino]phenyl]prop-2-enoate→2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
4-(4-(N,N-bis(2-hydroxyethyl)amino)benzylidene)2-phenyl-2-oxazolin-5-one→2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
4-[4-[N,N-bis(2-hydroxyethyl)amino]benzylidene]-4'-N,N-dimethylaminoaniline→2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	105 mg/kg	1.Gastrointestinal-hypermotility, diarrhea 2.Nutritional and Gross Metabolic-weight loss or decreased weight gain 3.Tumorigenic-active as anti-cancer agent
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	18 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	25 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

4-[4-[N,N-bis(2-hydroxyethyl)amino]benzylidene]-4'-N,N-dimethylaminoaniline
oxirane
methyl 2-benzamido-3-[4-[bis(2-hydroxyethyl)amino]phenyl]prop-2-enoate
4-(4-(N,N-bis(2-hydroxyethyl)amino)benzylidene)2-phenyl-2-oxazolin-5-one

Downstream Product

N-Acetylsarcolysine
DL-Alanine, 3-[p-bis(2-chloroethyl)aminophenyl]-N-formyl-

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