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2-(4-phenylphenyl)propanoic acid

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Origin: China

Cas No: 6341-72-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 6341-72-6 Formula: C15H14O2 Molecular Weight: 226.27000

Description

A metabolite of Isopropylbiphenyl, a COX-2 selective inhibitor. Also an impurity of Flurbiprofen.

Basic Info

Chemical Name	2-(4-phenylphenyl)propanoic acid
Synonyms	2-(4-Biphenylyl)-propionic acid; 2-(para-biphenyl)propanoic acid; 2-(Biphenyl-4-yl)propanoic acid; p-Phenylhydratropic Acid; 2-(p-Biphenyl)propionic acid; Biprofen; (RS)-2-(4'-biphenylyl)propanoic acid;
CAS No.	6341-72-6
Molecular Formula	C15H14O2
Molecular Weight	226.27000
PSA	37.30000
LogP	3.54170

Properties

Density	1.134g/cm3
Boiling Point	388.3ºC at 760 mmHg
Flash Point	285.1ºC
Refractive Index	1.582

Synthesis Route

2-chloro-1-(4-phenylphenyl)propan-1-one→2-(4-phenylphenyl)propanoic acid+4-Propionylbiphenyl
carbon dioxide+1-(1-chloroethyl)-4-phenylbenzene→2-(4-phenylphenyl)propanoic acid
Methyl 2-(4'-biphenylyl)propanoate→2-(4-phenylphenyl)propanoic acid

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Subcutaneous	TDLo - Lowest published toxic dose	Rodent - rat	45 mg/kg,female 5 day(s) pre-mating	1.Reproductive-Fertility-other measures of fertility
Subcutaneous	TDLo - Lowest published toxic dose	Rodent - rat	85 mg/kg,female 9 day(s) pre-mating	1.Reproductive-Maternal Effects-ovaries, fallopian tubes