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Picture of 2-(4-nitroanilino)ethanol

2-(4-nitroanilino)ethanol

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Origin: China

Cas No: 1965-54-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 1965-54-4 Formula: C8H10N2O3 Molecular Weight: 182.17700

    Description

    2-[(4-nitrophenyl)amino]ethanol is used to prepare phenylpurinediamine derivatives as a class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations of lung cancer. It is also used to synthesize benzannulated N-heterocycles via palladium-catalyzed domino intermolecular alkylation/intramolecular amination of functionalized aryl iodides and bromoalkylamines.

    Basic Info

    Chemical Name 2-(4-nitroanilino)ethanol
    Synonyms

    CAS No. 1965-54-4
    Molecular Formula C8H10N2O3
    Molecular Weight 182.17700
    PSA 78.08000
    LogP 1.59520

    Properties

    Density 1.352g/cm3
    Boiling Point 389.5ºC at 760mmHg
    Flash Point 189.4ºC
    Refractive Index 1.64
    Vapor Pressure 9.13E-07mmHg at 25°C

    Safety Info

    HS Code 2922199090

    Synthesis Route

    2-(4-nitrophenoxy)ethanamine,hydrochloride2-(4-nitroanilino)ethanol+N-(2-hydroxyethyl)-2-hydroxy-5-nitroaniline
    ethanolamine+4-Chloronitrobenzene2-(4-nitroanilino)ethanol+4-chloroaniline
    ethanolamine+4-Fluoronitrobenzene2-(4-nitroanilino)ethanol

    Precursor

    2-(4-nitrophenoxy)ethyl tosylate
    1,4-dinitrobenzene
    ethanolamine
    1-Iodo-4-nitrobenzene

    Downstream Product

    5198-52-7
    N-<Diaethylaminoaethyl>-p-nitro-anilin
    2-(1,6-diaminocyclohexa-2,4-dien-1-yl)ethanol
    4-N-(2-pyrrolidin-1-ylethyl)benzene-1,4-diamine

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