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2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

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Origin: China

Cas No: 1222-57-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 1222-57-7 Formula: C14H12N2O2S Molecular Weight: 272.32200

Description

Zolimidine (zoliridine, brand name Solimidin) is a gastroprotective drug previously used for peptic ulcer and gastroesophageal reflux disease.

Basic Info

Chemical Name	2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
Synonyms	Zolimidine; Zolimidin; EINECS 214-947-4;
CAS No.	1222-57-7
Molecular Formula	C14H12N2O2S
Molecular Weight	272.32200
PSA	59.82000
LogP	3.48560

Properties

Density	1.31 g/cm3
Refractive Index	1.653

Safety Info

HS Code	2933990090

Synthesis Route

2-Aminopyridine+4'-(Methylsulfonyl)acetophenone→2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
2-(4-methylsulfanylphenyl)imidazo[1,2-a]pyridine→2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
pyridine+N-{1-[4-(methylsulfonyl)phenyl]ethylidene}-4H-1,2,4-triazol-4-amine→2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	280.	2927.	isothermal

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	3710 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	950 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	4400 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

4'-(Methylsulfonyl)acetophenone
N-{1-[4-(methylsulfonyl)phenyl]ethylidene}-4H-1,2,4-triazol-4-amine
2-(4-methylsulfanylphenyl)imidazo[1,2-a]pyridine
pyridine

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