Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate

[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate

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Origin: China

Cas No: 194154-40-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 194154-40-0 Formula: C22H28N6O7 Molecular Weight: 488.49400

Basic Info

Chemical Name	[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate
Synonyms	mono-benzyloxycarbonyl-L-valine ganciclovir; CBZ-protected mono-L-valyl ester of ganciclovir; 2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3 hydroxy-1-propyl-N-(benzyloxycarbonyl)-L-valinate; N-Carbobenzyloxy-L-valinyl-ganciclovir; Cbz-Valine ganciclovir; CBZ-valganciclovir; N-carbobenzyloxy-mono-VGNC;
CAS No.	194154-40-0
Molecular Formula	C22H28N6O7
Molecular Weight	488.49400
PSA	180.69000
LogP	0.80030

Properties

Appearance & Physical State	White solid
Density	1.46g/cm3

Synthesis Route

N-Carbobenzyloxy-L-valine+[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate→[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate
[3-acetyloxy-2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]propyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate→[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate
(2S,2'S)-2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)propane-1,3-diyl bis(2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate)→[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate

Precursor

ganciclovir
(2S,2'S)-2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)propane-1,3-diyl bis(2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate)
[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate
[3-acetyloxy-2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]propyl] (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate

Downstream Product

Valganciclovir hydrochloride

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