Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> (1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol

(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol

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Origin: China

Cas No: 118457-16-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 118457-16-2 Formula: C22H25F2NO4 Molecular Weight: 405.43500

Description

A β1-Adrenergic blocker. Used as an antihypertensive.

Basic Info

Chemical Name	(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
Synonyms	UNII-GMK2E335DQ; l-nebivolol; Levonebivolol;
CAS No.	118457-16-2
Molecular Formula	C22H25F2NO4
Molecular Weight	405.43500
PSA	70.95000
LogP	2.75450

Properties

Density	1.309g/cm3
Boiling Point	600.5ºC at 760mmHg
Flash Point	316.9ºC
Refractive Index	1.58
Vapor Pressure	2.88E-15mmHg at 25°C

Synthesis Route

N-[(S,S)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(R,S)-1-hydroxy-2-(6-fiuoro-chroman-4-one-2-yl)]-amine→(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
[2R,αS,2'S,α'S]-α-α'-[[(phenylmethyl)imino]bis-methylene]bis[6-fluoro-3,4-dehydro-2H-1-benzopyran-2-methanol] hydrochloride→(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
(2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane+→(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol

Precursor

N-[(S,S)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(R,S)-1-hydroxy-2-(6-fiuoro-chroman-4-one-2-yl)]-amine
(2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane
[2R,αS,2'S,α'S]-α-α'-[[(phenylmethyl)imino]bis-methylene]bis[6-fluoro-3,4-dehydro-2H-1-benzopyran-2-methanol] hydrochloride

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