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(1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

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Origin: China

Cas No: 79836-45-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 79836-45-6 Formula: C17H17Cl2N Molecular Weight: 306.23000

Description

Used for the treatment of menopause and mood, anxiety, and cognitive disorders. They block uptake of dopamine and norepinephrine.

Basic Info

Chemical Name	(1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
Synonyms	rac-trans-(1S,4R)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalene; (rac)-trans-sertraline; Sertraline,(1RS,4SR); (1R,4S)-Trans-Sertraline; trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine; racemic sertraline; trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; UNII-4N6S45X78A; cis-racemate; Sertraline,trans-(+/-);
CAS No.	79836-45-6
Molecular Formula	C17H17Cl2N
Molecular Weight	306.23000
PSA	12.03000
LogP	5.57050

Properties

Density	1.255g/cm3
Boiling Point	416.33ºC at 760 mmHg
Flash Point	205.589ºC
Refractive Index	1.621
Storage Condition	Refrigerator

Synthesis Route

3,4-Dichlorobenzophenone→(1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid→(1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
3-(ethoxycarbonyl)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid→(1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

Precursor

4-(3,4-Dichloro Phenyl)-Tetralone
3-(ethoxycarbonyl)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid
4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid
3,4-Dichlorobenzophenone

Downstream Product

cis-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
4-(3,4-dichlorophenyl)-N-methyl-3,4-dihydro-2H-naphthalen-1-imine,hydrochloride

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