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Picture of (1R,2R,4R,6R,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-2,4,6,8,10,14-hexamethyl-6-[(E)-3-quinolin-3-ylprop-2-enoxy]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone


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Origin: China

CasNo: 205110-48-1

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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    CAS No.: 205110-48-1 Formula: C42H59N3O10 Molecular Weight: 765.93200


    Cethromycin, trade name Restanza (initially known as ABT-773) is a ketolide antibiotic undergoing research for the treatment of community acquired pneumonia (CAP) and for the prevention of post-exposure inhalational anthrax, and was given an "orphan drug" status for this indication. Originally discovered and developed by Abbott, it was acquired by Advanced Life Sciences Inc. for further development.
    On October 1, 2008 Advanced Life Sciences submitted a New Drug Application (NDA) to Food and Drug Administration (FDA) for cethromycin to treat mild-to-moderate community acquired pneumonia.
    On December 3, 2008 Advanced Life Sciences announced that this New Drug Application has been accepted for filing by the FDA.
    In June 2009, an FDA Anti-Infective Drugs Advisory Committee review found insufficient evidence for cethromycin efficacy in treatment of community acquired pneumonia, as the Phase 3 clinical trial followed standards that were updated after the clinical trial but three months prior to review. The committee did, however, find the drug safe to use.

    Basic Info

    Chemical Name (1R,2R,4R,6R,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-2,4,6,8,10,14-hexamethyl-6-[(E)-3-quinolin-3-ylprop-2-enoxy]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone

    ABT 773;

    CAS No. 205110-48-1
    Molecular Formula C42H59N3O10
    Molecular Weight 765.93200
    PSA 162.82000
    LogP 5.43850


    Density 1.22g/cm3
    Boiling Point 927.1ºC at 760mmHg
    Flash Point 514.5ºC
    Refractive Index 1.578
    Vapor Pressure 0mmHg at 25°C

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