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(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

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Origin: China

Cas No: 180272-45-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 180272-45-1 Formula: C15H15N Molecular Weight: 209.28600

Description

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin, an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.

Basic Info

Chemical Name	(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Synonyms	(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline;
CAS No.	180272-45-1
Molecular Formula	C15H15N
Molecular Weight	209.28600
PSA	12.03000
LogP	3.25050

Properties

Density	1.065 g/cm3
Boiling Point	338.4ºC at 760 mmHg
Flash Point	166.9ºC

Synthesis Route

1-Phenyl-3,4-dihydroisoquinoline→1-phenyl-1,2,3,4-tetrahydroisoquinoline+(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
N-benzyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Precursor

1-Phenyl-3,4-dihydroisoquinoline
N-benzyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Downstream Product

1-Phenyl-3,4-dihydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
ethyl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
Solifenacin

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