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Picture of (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

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Origin: China

CasNo: 180272-45-1

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Description
  • Property

    CAS No.: 180272-45-1 Formula: C15H15N Molecular Weight: 209.28600

    Description

    (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin, an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.

    Basic Info

    Chemical Name (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
    Synonyms

    (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline;

    CAS No. 180272-45-1
    Molecular Formula C15H15N
    Molecular Weight 209.28600
    PSA 12.03000
    LogP 3.25050

    Properties

    Density 1.065 g/cm3
    Boiling Point 338.4ºC at 760 mmHg
    Flash Point 166.9ºC

    Synthesis Route

    1-Phenyl-3,4-dihydroisoquinoline1-phenyl-1,2,3,4-tetrahydroisoquinoline+(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
    (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
    N-benzyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

    Precursor

    1-Phenyl-3,4-dihydroisoquinoline
    N-benzyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
    (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
    4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

    Downstream Product

    1-Phenyl-3,4-dihydroisoquinoline
    1-phenyl-1,2,3,4-tetrahydroisoquinoline
    ethyl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
    Solifenacin

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