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17-β-ESTRADIOL 3-METHYL ETHER

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Origin: China

Cas No: 1474-53-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 1474-53-9 Formula: C19H26O3 Molecular Weight: 302.40800

Basic Info

Chemical Name	17-β-ESTRADIOL 3-METHYL ETHER
Synonyms	3-Methoxyestriol; 3-methoxy-14-acetoxydibenz<a,j>anthracene;
CAS No.	1474-53-9
Molecular Formula	C19H26O3
Molecular Weight	302.40800
PSA	49.69000
LogP	2.88300

Properties

Density	1.185g/cm3
Boiling Point	450.8ºC at 760mmHg
Flash Point	226.4ºC
Refractive Index	1.588
Vapor Pressure	6.48E-09mmHg at 25°C

Safety Info

Safety Statements	36/37
Risk Statements	R40
Hazard Codes	Xn

Synthesis Route

estriol+dimethyl sulfate→17-β-ESTRADIOL 3-METHYL ETHER
(8R,9S,13S,14S,17R)-17-hydroxy-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,17-decahydro-16H-cyclopenta[a]phenanthren-16-one→17-β-ESTRADIOL 3-METHYL ETHER+1,3,5(10)-ESTRATRIEN-3,16-β, 17-β-TRIOL 3-METHYL ETHER
diazomethane+estriol→17-β-ESTRADIOL 3-METHYL ETHER

Precursor

diazomethane
Tetramethylammonium hydroxide
(8R,9S,13S,14S,17R)-17-hydroxy-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,17-decahydro-16H-cyclopenta[a]phenanthren-16-one
dimethyl sulfate

Downstream Product

3-Methoxyestra-1,3,5(10)-trien-17-one
Estra-1,3,5(10)-trien-17-one, 3-methoxy-, oxime
estriol

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