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1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone

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Origin: China

Cas No: 39552-01-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 39552-01-7 Formula: C16H21NO4 Molecular Weight: 291.34200

Description

Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs.

Basic Info

Chemical Name	1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
Synonyms	Befunolol HCl;
CAS No.	39552-01-7
Molecular Formula	C16H21NO4
Molecular Weight	291.34200
PSA	71.70000
LogP	2.76400

Safety Info

HS Code	2932999099

Synthesis Route

3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidone→1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
2-acetyl-7-(2-hydroxy-3-aminopropoxy)benzofuran+2-Bromopropane→1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
2-phenyl-3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidine→1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	100 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

2-Bromopropane
3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidone
2-phenyl-3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidine
2-acetyl-7-[2-hydroxy-3-(N-acetyl-N-isopropyl)aminopropoxy]benzofuran

Downstream Product

1-[[2-(2-hydroxyethyl)-1-benzofuran-7-yl]oxy]-3-(propan-2-ylamino)propan-2-ol

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