Home > Heterocyclic Compounds> 1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

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Origin: China

Cas No: 3416-05-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 3416-05-5 Formula: C10H14N2O4 Molecular Weight: 226.22900

Basic Info

Chemical Name	1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Synonyms	ddT & GM-CSF; Thymidine,2',3'-dideoxy; 2'-3'-didehydro-2'-3'-dideoxythymidine; 1-((2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 2',3'-dideoxy-2',3'-didehydro-thymydine; D-3'-deoxythymidine; 5-methyl-2',3'-dideoxyuridine; 2',3'-dihydro-3'-deoxythymidine; 2',3'-dideoxythymidine; 3'-Deoxythymidine; Dideoxythymidine;
CAS No.	3416-05-5
Molecular Formula	C10H14N2O4
Molecular Weight	226.22900
PSA	84.32000
LogP	-0.48510

Properties

Density	1.332g/cm3
Melting Point	155-156ºC
Refractive Index	1.551
Storage Condition	2-8ºC

Safety Info

Safety Statements	S22-S24/25
WGK Germany	3

Synthesis Route

3'-O-(1,3-benzodithiol-2-yl)-5'-O-trityl-N3-benzoyl-thymidine→1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione+1-[(2R,4S,5R)-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
stavudine→1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
thymidine→1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

Precursor

(2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid methyl ester
1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pentofuranosyl]thymine
stavudine
thymidine

Downstream Product

5-(Hydroxymethyl)-1-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furany l]-2,4(1H,3H)-pyrimidinedione
zalcitabine
ddU-2,5'-anhydro-5-Me
ribothymidine

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