Home > Organosilicon Compounds> 1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

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Origin: China

Cas No: 40733-27-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 40733-27-5 Formula: C16H28N2O5Si Molecular Weight: 356.48900

Basic Info

Chemical Name	1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Synonyms	TBS-T; 3'-DiTBSRiboT;
CAS No.	40733-27-5
Molecular Formula	C16H28N2O5Si
Molecular Weight	356.48900
PSA	93.55000
LogP	1.51520

Synthesis Route

5'-O-TERT-BUTYLDIMETHYLSILYL-THYMIDINE→thymine+1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Methanol+5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-(tert-butyldimethylsilyl)thymidine→1-methoxy-4-[methoxy-(4-methoxyphenyl)-phenylmethyl]benzene+1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
tert-butyldimethylsilyl chloride+5'-O-(4,4'-Dimethoxytrityl)thymidine→bis(4-methoxyphenyl)-phenylmethanol+1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	OV-1	230.	2587.	isothermal

Precursor

Triphenylmethyl Chloride
5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-(tert-butyldimethylsilyl)thymidine
1H-imidazole
3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE

Downstream Product

5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE
Thymidine-5'-carboxylic acid
thymine
thymidine

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