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1-[(2-fluorophenyl)methyl]-4-methylsulfonylpiperazine

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Origin: China

Cas No: 60384-53-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 60384-53-4 Formula: C12H17FN2O2S Molecular Weight: 272.33900

Description

The (+) enantiomer of Galanthamine.

Basic Info

Chemical Name	1-[(2-fluorophenyl)methyl]-4-methylsulfonylpiperazine
Synonyms	(+/-)-(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; (+/-)galanthamine; 1-(2-Fluoro-benzyl)-4-methanesulfonyl-piperazine;
CAS No.	60384-53-4
Molecular Formula	C12H17FN2O2S
Molecular Weight	272.33900
PSA	49.00000
LogP	1.85950

Properties

Appearance & Physical State	Off-White Solid
Density	1.28g/cm3
Boiling Point	439.3ºC at 760 mmHg
Melting Point	123-126ºC
Flash Point	219.5ºC
Refractive Index	1.636

Synthesis Route

4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ethylene ketal→1-[(2-fluorophenyl)methyl]-4-methylsulfonylpiperazine
(8aS)-1-bromo-3-methoxy-11-methyl-4a,5,10,11-tetrahydrospiro[benzo[2,3]benzofuro[4,3-cd]azepine-6,2'-[1,3]dioxolan]-12(9H)-one→1-[(2-fluorophenyl)methyl]-4-methylsulfonylpiperazine
4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one→1-[(2-fluorophenyl)methyl]-4-methylsulfonylpiperazine

Precursor

4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ethylene ketal
4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one
(8aS)-1-bromo-3-methoxy-11-methyl-4a,5,10,11-tetrahydrospiro[benzo[2,3]benzofuro[4,3-cd]azepine-6,2'-[1,3]dioxolan]-12(9H)-one

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