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(-)-Eburnamonine

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Origem: China

Cas No: 4880-88-0

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 100 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Especificação de produtos
  • Descrição do produto

  • Quick Details

    CAS No.:
    4880-88-0
    Other Names:
    Vinburnine
    MF:
    Vinburnine
    EINECS No.:
    Vinburnine
    Place of Origin:
    Anhui, China
    Type:
    Other
    Grade Standard:
    Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade, Tech Grade
    Usage:
    Animal Pharmaceuticals
    Brand Name:
    joye
    Purity:
    99%

    Packaging&Delivery

    Packaging Details
    25kgs/carton
    Port
    shanghai,ningbo,tianjin,guangzhou,qingdao,dalian
    Lead Time:
    Quantity(Kilograms)1 - 1>1
    Est. Time(days)15To be negotiated

  • Property

    CAS No.: 4880-88-0 Formula: C19H22N2O Molecular Weight: 294.39100

    Description

    Vinburnine (or eburnamonine, Vincamone) is a vasodilator. Vincamone is a vinca alkaloid and a metabolite of vincamine.

    Basic Info

    Chemical Name (-)-Eburnamonine
    Synonyms

    (-)-EBURNAMONINE;

    CAS No. 4880-88-0
    Molecular Formula C19H22N2O
    Molecular Weight 294.39100
    PSA 25.24000
    LogP 3.71250

    Properties

    Appearance & Physical State white powder
    Density 1.34 g/cm3
    Boiling Point 441.9ºC at 760 mmHg
    Melting Point 173-177ºC
    Flash Point 221ºC

    Safety Info

    RTECS YY8575570
    Safety Statements S24/25
    HS Code 2933990090
    WGK Germany 2

    Synthesis Route

    14,15-dihydro-1,14-seco-eburnamenin-14-ol→(-)-Eburnamonine
    (-)-methyl 1,2,3,4,6,7,12,12bα-octahydroindolo(2,3-a)quinolizine(1β-yl) pyruvate oxime→(-)-Eburnamonine
    (1S,12bS)-1-ethyl-1-(2-hydroxyethyl)-4-oxo-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine→(-)-Eburnamonine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 3 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse 265 mg/kg 1.Sense Organs and Special Senses (Eye)-lacrimation
    2.Behavioral-convulsions or effect on seizure threshold
    3.Gastrointestinal-changes in structure or function of salivary glands
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - mouse 28 mg/kg 1.Sense Organs and Special Senses (Eye)-lacrimation
    2.Behavioral-convulsions or effect on seizure threshold
    3.Gastrointestinal-changes in structure or function of salivary glands

    Precursor

    14,15-dihydro-1,14-seco-eburnamenin-14-ol
    (-)-methyl 1,2,3,4,6,7,12,12bα-octahydroindolo(2,3-a)quinolizine(1β-yl) pyruvate oxime
    (4R,5S)-3-[(2S)-1-oxo-2-ethyl-4-pentenyl]-4-methyl-5-phenyl-2-oxazolidinone
    (1S,12bS)-1-ethyl-1-(2-hydroxyethyl)-4-oxo-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine

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