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(±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride

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Origin: China

Cas No: 90182-92-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 90182-92-6 Formula: C15H20ClN3O2 Molecular Weight: 309.79100

Description

Zacopride is a potent antagonist at the 5-HT3 receptor and an agonist at the 5-HT4 receptor. It has anxiolytic and nootropic effects in animal models, with the (R)-(+)-enantiomer being the more active form. It also has antiemetic and pro-respiratory effects, both reducing sleep apnea and reversing opioid-induced respiratory depression in animal studies. Early animal trials have also revealed that administration of zacopride can reduce preference for and consumption of ethanol.
Zacopride was found to significantly increase aldosterone levels in human subjects for 180 minutes at a dose of 400 micrograms. It is thought to do this by stimulating the 5-HT4 receptors on the adrenal glands. Zacopride also stimulated aldosterone secretion when applied to human adrenal glands in vitro. No significant changes were observed in renin, ACTH, or cortisol levels.
Zacopride has been tested in clinical trials for the treatment of schizophrenia, but was found unsuccessful.

Basic Info

Chemical Name	(±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride
Synonyms	Zacoprida; Zacopride; Zacopridum; AHR-4964; ZacoprideHCl; AHR-4965;
CAS No.	90182-92-6
Molecular Formula	C15H20ClN3O2
Molecular Weight	309.79100
PSA	67.59000
LogP	2.66480

Properties

Density	1.33g/cm3
Boiling Point	456.5ºC at 760 mmHg
Flash Point	229.9ºC
Storage Condition	Desiccate at RT

Downstream Product

4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-hydroxybenzamide

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