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Главная > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Gastrointestinal tract/ metabolism> (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride
Изображение (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride

(±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride

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начало: Китай

Кас Но: 90182-92-6

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта

  • Property

    CAS No.: 90182-92-6 Formula: C15H20ClN3O2 Molecular Weight: 309.79100

    Description

    Zacopride is a potent antagonist at the 5-HT3 receptor and an agonist at the 5-HT4 receptor. It has anxiolytic and nootropic effects in animal models, with the (R)-(+)-enantiomer being the more active form. It also has antiemetic and pro-respiratory effects, both reducing sleep apnea and reversing opioid-induced respiratory depression in animal studies. Early animal trials have also revealed that administration of zacopride can reduce preference for and consumption of ethanol.
    Zacopride was found to significantly increase aldosterone levels in human subjects for 180 minutes at a dose of 400 micrograms. It is thought to do this by stimulating the 5-HT4 receptors on the adrenal glands. Zacopride also stimulated aldosterone secretion when applied to human adrenal glands in vitro. No significant changes were observed in renin, ACTH, or cortisol levels.
    Zacopride has been tested in clinical trials for the treatment of schizophrenia, but was found unsuccessful.

    Basic Info

    Chemical Name (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamidehydrochloride
    Synonyms

    Zacoprida;
    Zacopride;
    Zacopridum;
    AHR-4964;
    ZacoprideHCl;
    AHR-4965;

    CAS No. 90182-92-6
    Molecular Formula C15H20ClN3O2
    Molecular Weight 309.79100
    PSA 67.59000
    LogP 2.66480

    Properties

    Density 1.33g/cm3
    Boiling Point 456.5ºC at 760 mmHg
    Flash Point 229.9ºC
    Storage Condition Desiccate at RT

    Downstream Product

    4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-hydroxybenzamide

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