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(-)-1 4-DI-O-TOSYL-L-THREITOL

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Origin: China

Cas No: 57495-46-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 57495-46-2 Formula: C18H22O8S2 Molecular Weight: 430.49200

    Description

    L-Threitol-1,4-ditosylate is a tosyl protected L-Threitol, a intermediate used to synthesize novel aza-sugar-based metalloproteinase MMP/ADAM inhibitors.

    Basic Info

    Chemical Name (-)-1 4-DI-O-TOSYL-L-THREITOL
    Synonyms

    L-THREITOL 1,4-DI-P-TOSYLATE;
    1,4-ditosyl-L-threitol;

    CAS No. 57495-46-2
    Molecular Formula C18H22O8S2
    Molecular Weight 430.49200
    PSA 143.96000
    LogP 3.29760

    Properties

    Density 1.397g/cm3
    Boiling Point 657.6ºC at 760mmHg
    Flash Point 351.5ºC

    Synthesis Route

    (4S,5S)-(-)-4,5-Bis(tosyloxymethyl)-2,2-dimethyl-1,3-dioxolane→(-)-1 4-DI-O-TOSYL-L-THREITOL
    p-Toluenesulfonyl chloride→(-)-1 4-DI-O-TOSYL-L-THREITOL

    Precursor

    (4S,5S)-(-)-4,5-Bis(tosyloxymethyl)-2,2-dimethyl-1,3-dioxolane
    p-Toluenesulfonyl chloride

    Downstream Product

    (3S,4S)-1-Benzylpyrrolidine-3,4-diol
    (S,S)-butane-2,3-diol

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