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Trimethoxymethane

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Origin: China

Cas No: 149-73-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
149-73-5
Other Names:
Trimethoxymethane
MF:
C4H10O3
EINECS No.:
205-745-7
Place of Origin:
Shanghai, China
Grade Standard:
Agriculture Grade, Electron Grade, Food Grade, Industrial Grade, Medicine Grade
Purity:
99%
Appearance:
colorless liquid
Application:
industrial
Brand Name:
Terppon
Model Number:
Terppon A
color:
colorless
Packaging&Delivery
Packaging Details
in 200kg drum
Port
SHANGHAI
Lead Time:
1 week

Property

CAS No.: 149-73-5 Formula: C4H10O3 Molecular Weight: 106.12000

Description

Trimethyl orthoformate is the simplest orthoester. It is a reagent used in organic synthesis for the introduction of a protecting group for aldehydes. The product of reaction of an aldehyde with trimethyl orthoformate is an acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.
The industrial synthesis of this chemical is from hydrogen cyanide and methanol.
Trimethyl orthoformate is a useful building block for creating methoxymethylene groups and heterocyclic ring systems. It introduces a formyl group to a nucleophilic substrate, e.g. RNH2 to form R-NH-CHO, which can undergo further reactions. It is used in the production of the fungicides, azoxystrobin and picoxystrobin, as well as for some members of the floxacin family of antibacterial drugs. A number of pharmaceutical intermediates are also made from trimethyl orthoformate.

Basic Info

Chemical Name	Trimethoxymethane
Synonyms	Methane,trimethoxy; anhydrous trimethyl orthoformate; Orthoformic Acid Trimethyl Ester; Methyl orthoformate; Orthoformic acid methyl ester; TRIMETHYL ORTHOFORMATE; Methane, trimethoxy-; Orthomravencan methylnaty; trimethylortoformate; Orthoformic acid,trimethyl ester;
CAS No.	149-73-5
Molecular Formula	C4H10O3
Molecular Weight	106.12000
PSA	27.69000
LogP	0.20920

Properties

Appearance & Physical State	Colorless transparent liquid
Density	0.97
Boiling Point	101-102ºC
Melting Point	-53ºC
Flash Point	13ºC
Refractive Index	1.378-1.38
Water Solubility	10 g/L (hydrolysis)
Stability	Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Condition	Store at RT.
Vapor Density	3.67 (vs air)
Vapor Pressure	23.5 mm Hg ( 20 °C)

Safety Info

RTECS	RM6650000
Hazard Class	3
Safety Statements	S16-S26-S29-S9
HS Code	2915130000
WGK Germany	1
Packing Group	II
RIDADR	UN 3272 3
Risk Statements	R11; R36
Hazard Codes	F
Hazard Declaration	H225; H319
Caution Statement	P210; P305 + P351 + P338
Signal Word	Danger
Symbol	GHS02, GHS07

Synthesis Route

1,3-dioxolane+Methanol→2-Methoxy-1,3-dioxolane+4-methoxy-1,3-dioxolane
chloroform+Sodium methoxide→N,N-Dimethylformamide dimethyl acetal+Trimethoxymethane
chloroform+Sodium methoxide→N,N-Dimethylformamide dimethyl acetal+Trimethoxymethane

GC Analysis