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torcetrapib

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Origin: China

Cas No: 262352-17-0

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 262352-17-0 Formula: C26H22D3F9N2O4 Molecular Weight: 603.49200

    Description

    Torcetrapib (CP-529,414, Pfizer) was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease. Its development was halted in 2006 when phase III studies showed excessive all-cause mortality in the treatment group receiving a combination of atorvastatin (Lipitor) and torcetrapib.

    Basic Info

    Chemical Name torcetrapib
    Synonyms

    Torcetrapib;
    ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate;

    CAS No. 262352-17-0
    Molecular Formula C26H22D3F9N2O4
    Molecular Weight 603.49200
    PSA 59.08000
    LogP 8.26290

    Properties

    Appearance & Physical State lipid
    Density 1.42g/cm3
    Boiling Point 504.8ºC at 760mmHg
    Melting Point 54-58ºC
    Flash Point 259.1ºC
    Refractive Index 1.511
    Vapor Pressure 2.58E-10mmHg at 25°C

    Synthesis Route

    ethyl (2R,4S)-2-ethyl-4-(methoxycarbonylamino)-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate+1-(bromomethyl)-3,5-bis(trifluoromethyl)benzene→torcetrapib
    4-trifluoromethylaniline→torcetrapib
    (E)-pent-2-enoyl-carbamic acid methyl ester→torcetrapib

    Precursor

    (3R)-[3-(4-trifluoromethylphenylamino)pentanoyl]carbamic acid methyl ester
    (E)-pent-2-enoyl-carbamic acid methyl ester
    ethyl (2R,4S)-2-ethyl-4-(methoxycarbonylamino)-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
    1-(bromomethyl)-3,5-bis(trifluoromethyl)benzene

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