Home > Chiral Compounds> TNP 470,N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester

TNP 470,N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester

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Origin: China

Cas No: 129298-91-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 129298-91-5 Formula: C19H28ClNO6 Molecular Weight: 401.88200

Description

TNP-470 is a synthetic analog of Fumagillin; a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis and shows promise as both an anti-infective and antiangiogenic agent.

Basic Info

Chemical Name	TNP 470,N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
Synonyms	Tnp-470; 6-O-chloroacetylcarbamoylfumagillol; AGM-1470;
CAS No.	129298-91-5
Molecular Formula	C19H28ClNO6
Molecular Weight	401.88200
PSA	89.69000
LogP	2.94530

Properties

Density	1.26g/cm3
Refractive Index	1.535

Synthesis Route

Chloroacetyl isocyanate+Fumagillol→TNP 470,N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester

Precursor

Chloroacetyl isocyanate
Fumagillol

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