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tirapazamine

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Origin: China

Cas No: 27314-97-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 27314-97-2 Formula: C7H6N4O2 Molecular Weight: 178.14800

Description

A bioreductive anticancer agent. Selectively toxic to cells under hypoxic conditions. An antineoplastic.

Basic Info

Chemical Name	tirapazamine
Synonyms	4-hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine; 3-Amino-1,2,4-benzotriazine 1,4-Dioxide; 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine SR 259075 SR 4233 Tirazone Win 59075; Tirapazamine; 3-Aminobenzo[e][1,2,4]triazine 1,4-dioxide;
CAS No.	27314-97-2
Molecular Formula	C7H6N4O2
Molecular Weight	178.14800
PSA	89.83000
LogP	1.25520

Properties

Appearance & Physical State	Orange-red crystalline powder
Density	1.68 g/cm3
Boiling Point	493.6ºC at 760 mmHg
Melting Point	220ºC
Flash Point	252.3ºC
Refractive Index	1.777
Storage Condition	2-8ºC
Vapor Pressure	0mmHg at 25°C

Safety Info

RTECS	DM0671500
Safety Statements	S26; S36
Risk Statements	R36/37/38
Hazard Codes	Xi
Symbol	GHS07
Caution Statement	P261; P305 + P351 + P338
Signal Word	Warning
Hazard Declaration	H315; H319; H335

Synthesis Route

1,2,4-benzotriazin-3-amine→1-oxido-1,2,4-benzotriazin-1-ium-3-amine+3-amino-1,2,4-benzotriazine 2-oxide
1-oxido-1,2,4-benzotriazin-1-ium-3-amine→tirapazamine
N-(1-oxy-benzo[e][1,2,4]triazin-3-yl)-acetamide→tirapazamine

Precursor

2-Nitroaniline
1,2,4-benzotriazin-3-amine
N-(1-oxy-benzo[e][1,2,4]triazin-3-yl)-acetamide
1-oxido-1,2,4-benzotriazin-1-ium-3-amine

Downstream Product

1,2,4-benzotriazin-3-amine
3-amino-1,2,4-benzotriazine 4-oxide
1-oxido-1,2,4-benzotriazin-1-ium-3-amine
2-deoxy-D-ribono-1,4-lactone

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