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ticlopidine

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Origin: China

Cas No: 55142-85-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 55142-85-3 Formula: C14H14ClNS Molecular Weight: 263.78600

Description

Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. However, because of its rare but serious side effects of neutropenia and thrombotic thrombocytopenic purpura it was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable. With the advent of newer and safer antiplatelet drugs such as clopidogrel and ticagrelor, its use remained limited.

Basic Info

Chemical Name	ticlopidine
Synonyms	UNII-OM90ZUW7M1; [14C]-Ticlopidine; Ticlopidina [INN-Spanish]; 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine; Ticlopidina; 1,2,3,4-tetrahydro-N-<(2-chlorophenyl)methyl>-thieno<3,2-c>pyridine; Ticlopidine [INN:BAN]; Ticlopidinum [INN-Latin]; Ticlopidinum; Ticlopidine (INN); Ticlid; 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-C]pyridine; 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;
CAS No.	55142-85-3
Molecular Formula	C14H14ClNS
Molecular Weight	263.78600
PSA	31.48000
LogP	3.89770

Safety Info

Safety Statements	S26; S27; S36/37/39; S45
HS Code	2934999090
WGK Germany	3
RIDADR	UN 3261 8/PG 3
Risk Statements	R34
Hazard Codes	C; Xi

Synthesis Route

2-(2-bromoethyl)-3-(bromomethyl)thiophene+2-Chlorobenzylamine→ticlopidine
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine+2-Chlorobenzyl chloride→ticlopidine
1-[(2-chlorophenyl)methyl]-4-oxo-3-piperidine acetaldehyde→ticlopidine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	220.	2090.	isothermal

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LDLo - Lowest published lethal dose	Human - man	336 mg/kg/47D-I	1.Lungs, Thorax, or Respiration-other changes 2.Blood-agranulocytosis 3.Blood-thrombocytopenia
Oral	TDLo - Lowest published toxic dose	Human - woman	600 mg/kg/60D-I	1.Blood-aplastic anemia 2.Blood-changes in bone marrow (not otherwise specified) 3.Nutritional and Gross Metabolic-body temperature increase
Oral	TDLo - Lowest published toxic dose	Human - man	429 mg/kg/6OD-I	1.Gastrointestinal-hypermotility, diarrhea