Welcome to GlobalChemMall

ALL CATEGORIES
Categories
Picture of ticlopidine

ticlopidine

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 55142-85-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

  • Products Specification
  • Product Description
  • Property

    CAS No.: 55142-85-3 Formula: C14H14ClNS Molecular Weight: 263.78600

    Description

    Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. However, because of its rare but serious side effects of neutropenia and thrombotic thrombocytopenic purpura it was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable. With the advent of newer and safer antiplatelet drugs such as clopidogrel and ticagrelor, its use remained limited.

    Basic Info

    Chemical Name ticlopidine
    Synonyms

    UNII-OM90ZUW7M1;
    [14C]-Ticlopidine;
    Ticlopidina [INN-Spanish];
    5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;
    5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine;
    Ticlopidina;
    1,2,3,4-tetrahydro-N-<(2-chlorophenyl)methyl>-thieno<3,2-c>pyridine;
    Ticlopidine [INN:BAN];
    Ticlopidinum [INN-Latin];
    Ticlopidinum;
    Ticlopidine (INN);
    Ticlid;
    5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-C]pyridine;
    5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;

    CAS No. 55142-85-3
    Molecular Formula C14H14ClNS
    Molecular Weight 263.78600
    PSA 31.48000
    LogP 3.89770

    Safety Info

    Safety Statements S26; S27; S36/37/39; S45
    HS Code 2934999090
    WGK Germany 3
    RIDADR UN 3261 8/PG 3
    Risk Statements R34
    Hazard Codes C; Xi

    Synthesis Route

    2-(2-bromoethyl)-3-(bromomethyl)thiophene+2-Chlorobenzylamineticlopidine
    4,5,6,7-Tetrahydrothieno[3,2-c]pyridine+2-Chlorobenzyl chlorideticlopidine
    1-[(2-chlorophenyl)methyl]-4-oxo-3-piperidine acetaldehydeticlopidine

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed SE-30 220. 2090. isothermal

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LDLo - Lowest published lethal dose Human - man 336 mg/kg/47D-I 1.Lungs, Thorax, or Respiration-other changes
    2.Blood-agranulocytosis
    3.Blood-thrombocytopenia
    Oral TDLo - Lowest published toxic dose Human - woman 600 mg/kg/60D-I 1.Blood-aplastic anemia
    2.Blood-changes in bone marrow (not otherwise specified)
    3.Nutritional and Gross Metabolic-body temperature increase
    Oral TDLo - Lowest published toxic dose Human - man 429 mg/kg/6OD-I 1.Gastrointestinal-hypermotility, diarrhea

    Precursor

    4,5,6,7-Tetrahydrothieno[3,2-c]pyridine
    2-Chlorobenzyl chloride
    2-(2-bromoethyl)-3-(bromomethyl)thiophene
    2-Chlorobenzylamine

    Downstream Product

    5-[(2-chlorophenyl)methyl]-6,7-dihydrothieno[3,2-c]pyridin-4-one
    5-[(2-chlorophenyl)methyl]-4,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2-one

Hot tags: ticlopidine, China, manufacturers, suppliers, factory, wholesale, low price, high quality