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thiodiglycol

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Origin: China

Cas No: 111-48-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 111-48-8 Formula: C4H10O2S Molecular Weight: 122.18600

    Description

    Thiodiglycol, or bis(2-hydroxyethyl)sulfide (also known as 2,2-thiodiethanol or TDE), is a viscous, clear to pale-yellow liquid used as a solvent. Its chemical formula is C4H10O2S, or HOCH2CH2SCH2CH2OH. It is miscible with acetone, alcohols, and chloroform. It is soluble in benzene, ether, and tetrachloromethane.
    Thiodiglycol is manufactured by reaction of 2-chloroethanol with sodium sulfide. It is structurally similar to diethylene glycol.
    Thiodiglycol has both polar and nonpolar solvent properties. It is used as a solvent in a variety of applications ranging from dyeing textiles to inks in some ballpoint pens. In chemical synthesis, it is used as a building block for protection products, dispersants, fibers, plasticizers, rubber accelerators, pesticides, dyes, and various other organic chemicals. In the manufacture of polymers, it is used as a chain transfer agent. As an antioxidant, it is used as an additive in lubricants.
    A relatively recent use (as of 2006) of thiodiglycol is as a mounting medium in microscopy. The ability to vary the refractive index of the medium by varying the concentration of TDE in an aqueous solution, plus its relative lack of toxicity makes it highly desirable for such use. The refractive index of the solution can be varied anywhere from near that of water (1.333) to that of glass (1.518).
    Thiodiglycol is a Chemical Weapons Convention schedule 2 chemical used in the production of sulfur-based blister agents such as mustard gas. Thiodiglycol is also a product of the hydrolysis of mustard gas. It can be detected in the urine of casualties.

    Basic Info

    Chemical Name thiodiglycol
    Synonyms

    2,2-DIMETHYL-CHROMAN-6-SULFONYL CHLORIDE;
    2-[(2-HYDROXYETHYL)THIO]ETHANOL;
    2,2'-Thiodiethanol;
    2-(2-hydroxyethylsulfanyl)ethanol;
    2,2-Thiodiethanol;
    THIODIETHANOL;
    Ethanol, 2,2‘-thiobis-;
    2 2'-THIODIETHANOL;
    THIODIGLYCOL;

    CAS No. 111-48-8
    Molecular Formula C4H10O2S
    Molecular Weight 122.18600
    PSA 65.76000
    LogP -0.29580

    Properties

    Appearance & Physical State clear colorless to slightly yellow liquid.
    Density 1.18
    Boiling Point 165ºC (14 mmHg)
    Melting Point -16ºC(lit.)
    Flash Point >230 °F
    Refractive Index 1.519-1.521
    Stability Stable. Incompatible with strong oxidizing agents. Reacts with a wide variety of compounds. Flammable.
    Storage Condition Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
    Vapor Pressure 0.047mmHg at 25°C

    Safety Info

    RTECS KM2975000
    Safety Statements S23; S26; S36/37/39; S45
    HS Code 2930909026
    WGK Germany 1
    Risk Statements R36
    Hazard Codes Xi

    Synthesis Route

    Ethanol+bis(2-chloroethyl) sulfidethiodiglycol+1-ethoxy-2-(2-ethoxyethylsulfanyl)ethane
    3-(2-hydroxyethylsulfanyl)-3-[[4-hydroxy-2-(2-hydroxyethyl)-2-(2-hydroxyethylsulfanyl)butyl]sulfanylmethyl]pentane-1,5-diolthiodiglycol+2-(2-chloroethylsulfanyl)ethanol
    2-chloroethanolthiodiglycol

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 6610 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 4 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - mouse 4 gm/kg 1.Gastrointestinal-other changes
    2.Liver-hepatitis (hepatocellular necrosis), diffuse
    3.Endocrine-other changes

    Precursor

    oxirane
    mercaptoethanol
    2-chloroethanol
    2-(2-chloroethylsulfanyl)ethanol

    Downstream Product

    2-(2-hydroxyethylsulfanyl)ethyl acetate
    (2S)-2-amino-5-[2-(2-hydroxyethylsulfanyl)ethoxy]-5-oxopentanoate
    1,3-dicyclohexylurea
    1,4-dithiane

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