Home > Chiral Compounds> Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate

Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate

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Origin: China

Cas No: 144164-11-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
144164-11-4
Other Names:
Ritonavir intermediate
MF:
C23H27N3O3S
Place of Origin:
China
Type:
Pharmaceutical Intermediates
Purity:
99%MIN
Brand Name:
Royal pharm
Model Number:
Ritonavir intermediate
Application:
Used
Appearance:
solid
MW:
425.54
Packaging&Delivery
Packaging Details
Drum&plastic bags or Aluninium foiled bag&zip lock bag
Port
HangZhou
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 3 To be negotiated

Property

CAS No.: 144164-11-4 Formula: C23H27N3O3S Molecular Weight: 425.54400

Description

An intermediate in the synthesis of Ritonavir.

Basic Info

Chemical Name	Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
Synonyms	2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane;
CAS No.	144164-11-4
Molecular Formula	C23H27N3O3S
Molecular Weight	425.54400
PSA	125.71000
LogP	4.39280

Properties

Appearance & Physical State	Light yellow oil
Density	1.251g/cm3
Boiling Point	656.1ºC at 760 mmHg
Flash Point	350.6ºC
Refractive Index	1.619
Vapor Pressure	4.17E-18mmHg at 25°C

Synthesis Route

tert-Butyl (thiazol-5-ylmethyl) ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
(2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane+((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate→Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
(2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane+((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate→Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate

Precursor

tert-Butyl (thiazol-5-ylmethyl) ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate
(4S,6S,1'S)-6-(1-amino-2-phenylethyl)-4-benzyl-2-phenyl-3-aza-2-bora-1-oxacyclohexane
(2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

Downstream Product

ritonavir

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